Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51332
Gene Symbol: SPTBN5
SPTBN5
0.100 GeneticVariation disease GWASCAT A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans. 31241743 2019
Entrez Id: 9398
Gene Symbol: CD101
CD101
0.040 Biomarker disease BEFREE Rezafungin (CD101) is a novel echinocandin antifungal agent currently in clinical development for the treatment of candidemia and invasive candidiasis. 29555631 2018
Entrez Id: 9398
Gene Symbol: CD101
CD101
0.040 Biomarker disease BEFREE CD101 IV is a novel echinocandin with distinctive pharmacokinetic properties that is being developed as a once-weekly treatment for candidemia and invasive candidiasis. 27919901 2017
Entrez Id: 9398
Gene Symbol: CD101
CD101
0.040 Biomarker disease BEFREE CD101 is currently being evaluated as a once-weekly intravenous (i.v.) infusion for the treatment of candidemia and invasive candidiasis. 29133552 2018
Entrez Id: 9398
Gene Symbol: CD101
CD101
0.040 Biomarker disease BEFREE CD101, a novel echinocandin with a long plasma half-life and enhanced stability, is in development for once-weekly IV administration for the treatment of candidemia and invasive candidiasis. 28826987 2017
Entrez Id: 64581
Gene Symbol: CLEC7A
CLEC7A
0.030 GeneticVariation disease BEFREE Screening for the DECTIN-1 Y238X polymorphism within a group of 142 patients undergoing HSCT was correlated with Candida colonization and candidemia. 19614557 2009
Entrez Id: 64581
Gene Symbol: CLEC7A
CLEC7A
0.030 Biomarker disease BEFREE Whereas the dectin-1/CARD9 signaling pathway is nonredundant in mucosal immunity to C. albicans, a partial deficiency of β-glucan recognition has a minor impact on susceptibility to candidemia. 21881131 2011
Entrez Id: 64581
Gene Symbol: CLEC7A
CLEC7A
0.030 GeneticVariation disease BEFREE The role of Candida species herein has recently been rediscovered since a 'loss-of-function' Y238X polymorphism in dectin-1, a C-type lectin receptor recognizing the β-1,3-glucan motif of Candida, resulted in diminished membrane expression and lower cytokine responses upon β-1,3-glucan recognition, and was associated with increased Candida colonization of SCT recipients, rendering them at risk for candidaemia. 21178438 2011
Entrez Id: 8864
Gene Symbol: PER2
PER2
0.020 Biomarker disease BEFREE The proportion of patients receiving treatment increased (65.5%, 79.4% and 74.7% in periods 1, 2 and 3, respectively, p = 0.04), and the median time from candidemia to treatment initiation decreased from 4 days in period 1 (range 0-32 days) to 2 days in period 2 (range 0-33 days) and 2 days in period 3 (range 0-14 days, p < 0.001). 30118654 2018
Entrez Id: 64170
Gene Symbol: CARD9
CARD9
0.020 AlteredExpression disease BEFREE Thus, Dok3 suppresses Card9 signaling, and disrupting Dok3-Card9 interaction or inhibiting PP1 activity represents therapeutic opportunities to develop drugs to combat candidaemia. 31180338 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.020 GeneticVariation disease BEFREE In the multivariable model, persistent candidemia was significantly associated with (odds ratio [95% confidence interval]): total parenteral nutrition (2.79 [1.26-6.17]), dialysis dependence (3.76 [1.46-8.64]), and the SNPs IL10 rs1800896 (3.45 [1.33-8.93]) and IL12B rs41292470 (5.36 [1.51-19.0]). 22144535 2012
Entrez Id: 8864
Gene Symbol: PER2
PER2
0.020 Biomarker disease BEFREE The study period was split into two periods, 2007 to 2010 (period 1) and 2011 to 2014 (period 2).The number of episodes of <i>C. albicans</i> and <i>C. parapsilosis</i> candidemia (<i>n</i> = 262 versus <i>n</i> = 170, respectively), the mean incidence (1.62 versus 1.36 episodes per 1,000 admissions, respectively), and the percentage of episodes caused by clusters (overall clusters [40% versus 12%] and tracking clusters [18% versus 3%], respectively) were significantly lower in period 2 than in period 1. 29743306 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.020 GeneticVariation disease BEFREE IL-10 production was higher in C. albicans-stimulated PBMC from volunteers bearing the TLR4 Asp299Gly polymorphism, and a similar tendency was observed in TLR4 Asp299Gly heterozygous patients who had recovered from candidemia. 16613760 2006
Entrez Id: 64170
Gene Symbol: CARD9
CARD9
0.020 GeneticVariation disease BEFREE No significant association between the single-nucleotide polymorphisms DECTIN-1 Y238X and CARD9 S12N and the prevalence of candidemia was found, despite the association of the DECTIN-1 238X allele with impaired in vitro and in vivo cytokine production. 21881131 2011
Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
0.010 Biomarker disease BEFREE Thirteen mostly nonsynonymous single nucleotide polymorphisms (SNPs) in genes encoding TLRs and signaling adaptors MyD88 and Mal/TIRAP were genotyped in 338 patients (237 white, 93 African American, 8 other race) with candidemia and 351 noninfected controls (263 white, 88 African American). 22301633 2012
Entrez Id: 79930
Gene Symbol: DOK3
DOK3
0.010 AlteredExpression disease BEFREE Thus, Dok3 suppresses Card9 signaling, and disrupting Dok3-Card9 interaction or inhibiting PP1 activity represents therapeutic opportunities to develop drugs to combat candidaemia. 31180338 2019
Entrez Id: 199834
Gene Symbol: LCE4A
LCE4A
0.010 GeneticVariation disease BEFREE We observe significant association between candidaemia and SNPs in the CD58 (P = 1.97 × 10(-11); odds ratio (OR) = 4.68), LCE4A-C1orf68 (P = 1.98 × 10(-10); OR = 4.25) and TAGAP (P = 1.84 × 10(-8); OR = 2.96) loci. 25197941 2014
Entrez Id: 117289
Gene Symbol: TAGAP
TAGAP
0.010 GeneticVariation disease BEFREE We observe significant association between candidaemia and SNPs in the CD58 (P = 1.97 × 10(-11); odds ratio (OR) = 4.68), LCE4A-C1orf68 (P = 1.98 × 10(-10); OR = 4.25) and TAGAP (P = 1.84 × 10(-8); OR = 2.96) loci. 25197941 2014
Entrez Id: 53828
Gene Symbol: FXYD4
FXYD4
0.010 Biomarker disease BEFREE Candida parapsilosis was the most common species causing candidemia in the 2010 China Hospital Invasive Fungal Surveillance Net (CHIF-NET) database. 26282840 2015
Entrez Id: 965
Gene Symbol: CD58
CD58
0.010 Biomarker disease BEFREE We observe significant association between candidaemia and SNPs in the CD58 (P = 1.97 × 10(-11); odds ratio (OR) = 4.68), LCE4A-C1orf68 (P = 1.98 × 10(-10); OR = 4.25) and TAGAP (P = 1.84 × 10(-8); OR = 2.96) loci. 25197941 2014
Entrez Id: 10451
Gene Symbol: VAV3
VAV3
0.010 GeneticVariation disease BEFREE In this context, Vav3 is the single most important Vav in mice, and a polymorphism in human VAV3 is associated with susceptibility to candidemia in patients. 27926862 2016
Entrez Id: 284697
Gene Symbol: BTBD8
BTBD8
0.010 GeneticVariation disease BEFREE Based on logistic regression modelling, admission to north Indian ICUs [OR 2.1 (1.2-3.8); P  =   0.012], public-sector hospital [OR 2.2 (1.2-3.9); P  =   0.006], underlying respiratory illness [OR 2.1 (1.3-3.6); P  =   0.002], vascular surgery [OR 2.3 (1.00-5.36); P  =   0.048], prior antifungal exposure [OR 2.8 (1.6-4.8); P  <   0.001] and low APACHE II score [OR 0.8 (0.8-0.9); P  =   0.007] were significantly associated with C. auris candidaemia. 28333181 2017
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.010 Biomarker disease BEFREE ABC and microsatellite genotyping of 51 strains of C. albicans revealed that patients who did not develop candidaemia were multiply colonised by at least two ABC genotypes of C. albicans, whereas candidaemic patients had highly related microsatellites and the same ABC genotype in colonising and bloodstream isolates that were probably present in different body sites before the onset of candidaemia. 22415258 2012
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.010 GeneticVariation disease BEFREE Our aim was to assess the effect of genetic variations in the ATG16L1 and IRGM autophagy genes on the susceptibility of patients with candidemia and oropharyngeal candidiasis. 24713404 2014
Entrez Id: 406993
Gene Symbol: MIR211
MIR211
0.010 Biomarker disease BEFREE Administration of miR-204/miR-211 mimics substantially downregulated Hmx1 and mitigated the severity of the kidney injuries induced by Candidemia, as reflected by improved renal glomerular filtration rate (GFR) determined by serum cystatin C (CysC), serum β2-microglobulin (β2-MG) and blood urea nitrogen (BUN). 24641951 2014