We have identified the cardiomyopathy-susceptibility gene vinculin (<i>VCL</i>) mutation M94I may account for a sudden unexplained nocturnal death syndrome (SUNDS) case.
The VCL-encoding protein was involved in cardiomyopathy that associated with hypertension, therefore our results suggest the rs4746172 of VCL may be a novel target for clinical interventions to reduce CVD risk by regulating blood pressure in male Chinese.
Finally, the cardiomyopathy associated DeltaLeu954 and Arg975Trpmetavinculin mutants reside on the replaced extended coil and the H1' alpha-helix, respectively.