Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease CLINVAR
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease HPO
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 CausalMutation disease CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GenomicAlterations disease CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE PTEN mutations were not detected in 13 families at high risk of breast and/or ovarian cancer. 9399897 1997
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE The identification of frequent somatic PTEN mutations in endometrioid ovarian tumors indicates that it plays a significant role in the etiology of this subtype. 9605750 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer. 9625810 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE PTEN mutations were detected not only in the endometrioid type but also in the serous and mucinous types of ovarian cancer. 10629071 2000
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 CausalMutation disease CLINVAR Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. 11504908 2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE It is for the purpose of this study to investigate its function and the mechanisms by which PTEN enhances the sensitivity of ovarian cancer to antitumor agents. 12006545 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE PTEN, a tumor suppressor commonly mutated (50%) in endometrial carcinoma, is found mutated in endometrioid carcinoma of the ovary, but not in other forms of ovarian cancer. 11949955 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 PosttranslationalModification disease BEFREE This study was performed to investigate the hypermethylation status of the PTEN gene in ovarian cancer. 15072831 2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE We identified a frequency of molecular alterations in both independent and metastatic tumors, including microsatellite instability (uterine tumors, 50% and 67%, respectively; ovarian tumors, 33% and 67%) and PTEN mutations (uterine tumors, 38% and 100%; ovarian tumors, 33% and 83%) that is higher than that observed in single sporadic tumors. 16021566 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE We aimed to evaluate frequency of PTEN mutation, LOH and expression in ovarian tumors. 16793127 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE Between 2002-2005, probands from 300 US families with 4 or more cases of breast or ovarian cancer but with negative (wild-type) commercial genetic test results for BRCA1 and BRCA2 were screened by multiple DNA-based and RNA-based methods to detect genomic rearrangements in BRCA1 and BRCA2 and germline mutations of all classes in CHEK2, TP53, and PTEN. 16551709 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE Taken together, these data suggest that PTEN over-expression may represent a novel therapeutic approach for chemoresistant human ovarian cancer and that this may involve a p53-mediated apoptotic cascade independent of the PI3K/Akt pathway. 16545436 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE BRCA1 and BRCA2 mutations confer very high risks of breast and ovarian cancer. p53 and PTEN mutations lead to very high breast cancer risks associated with rare cancer syndromes. 17292821 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease LHGDN MMAC tumor supressor gene expression in ovarian endometriosis and ovarian adenocarcinoma. 17713092 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE These findings indicate that deregulation of miRNAs is a recurrent event in human ovarian cancer and that miR-214 induces cell survival and cisplatin resistance primarily through targeting the PTEN/Akt pathway. 18199536 2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 CausalMutation disease CLINVAR PTEN and the PI3-kinase pathway in cancer. 18767981 2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE Furthermore, we demonstrated that knockdown of miR-21 significantly increased the expression of PTEN, a known tumor suppressor in ovarian cancer. 21042775 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 CausalMutation disease CLINVAR The PI3K pathway as drug target in human cancer. 20085938 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease CTD_human Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma. 21372221 2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE PTEN, a tumor suppressor gene, has been demonstrated to be able to reverse cisplatin-resistance in ovarian cancer cell line C13K. 24434152 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Subcutaneously transplanted nude mice, as a model of human ovarian cancer, were used to test the effects of PTEN and KRT10 on cisplatin resistance of ovarian cancer in vivo. 26125866 2015