Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease BEFREE Sequence mutations and gene amplifications lead to activation of the PIK3CA-AKT2 signaling pathway and have been reported in several types of neoplasms including ovarian cancer. 16721043 2006
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease BEFREE We also found that an activating (E545K) Pik3ca mutation, unlike Pten inactivation or Pik3ca H1047R mutation, cannot cooperate with Arid1a loss to promote ovarian cancer development in the mouse. 26279473 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease BEFREE PIK3CA gene encoding a catalytic subunit of the PI3K is mutated and/or amplified in various neoplasms, including ovarian cancer. 19029838 2009
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease BEFREE Interaction between PIK3CA rs3976507 and rs6443626 loci, and factors such as BMI, number of liveborn, tobacco, alcohol, and family history of ovarian cancer are associated with ovarian cancer risk. 31288947 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease BEFREE Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer. 26909613 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease LHGDN PIK3CA mutations in ovarian cancer. 16203798 2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease CLINVAR
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease BEFREE Loss of HDAC-Mediated Repression and Gain of NF-κB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer. 27681437 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Activation of the PI3K/mTOR pathway has been shown to be correlated with resistance to chemotherapy in ovarian cancer. 29371953 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Likewise, the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is also a central regulator of the ovarian cancer. 29401696 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease HPO
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE These data suggested that PI3K induced epithelial-to-mesenchymal transition and promoted cell migration and invasion by activating the PI3K/AKT pathway in ovarian cancer. 30245957 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics. 31284467 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Here, we outline the importance of PI3K/AKT/mTOR signaling pathway in OC tumorigenesis, proliferation and progression, and pre-clinical and clinical experience with several PI3K/AKT/mTOR pathway inhibitors in OC. 31128298 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE The gene of phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) has been implicated as an oncogene in ovarian cancer [L. Shayesteh et al., Nat.Genet., 21: 99-102, 1999]. 12874030 2003
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Here, we show that dual inhibition of PI3K/mTOR in ovarian cancer-spheroids leads to death of inner matrix-deprived cells, whereas matrix-attached cells are resistant. 22340595 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE We assayed a number of food phytochemicals with reported PI3K inhibitory ability to identify candidates that can influence CDDP treatment outcomes in chemoresistant OVCA cell lines. 24247248 2014
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Synergistic effects of SHP2 and PI3K pathway inhibitors in GAB2-overexpressing ovarian cancer. 30755818 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. 29743815 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Our in vivo data suggests that PIK3CA activation is one of the early genetic events in ovarian cancer. 19172191 2009
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE miR-214 targets the PTEN-mediated PI3K/Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer. 29113199 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Effects of Per2 overexpression on growth inhibition and metastasis, and on MTA1, nm23-H1 and the autophagy-associated PI3K/PKB signaling pathway in nude mice xenograft models of ovarian cancer. 27082164 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease LHGDN Gain and/or amplification of PIK3CA gene, encoding the catalytic subunit of phosphatidylinositol 3-kinase (p110 alpha) and its increased expression are associated with enhanced PI3K activity in ovarian cancer cell lines. 17377809 2007
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE The phosphatidylinositol 3-kinase (PI3K) pathway is one of the critical signaling cascades playing important roles in the chemoresistance of human cancer cells, including ovarian cancer. 23371322 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Activation of the FOXM1 signaling pathway and the PI3K/AKT/mTOR signaling pathway is associated with poor prognosis in ovarian cancer. 30129654 2018