Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease HPO
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease CTD_human
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 CausalMutation disease CGI
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease CLINVAR
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Our observations suggest PIK3CA is an oncogene that has an important role in ovarian cancer. 9916799 1999
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE These data demonstrate that different repertoires of downstream signaling proteins, particularly those of the MEK6-p38 MAPK-CK2 pathway and the PI3K pathway, are correlated with phenotypic manifestations of a cell culture model of OSE at progressive stages in the development of ovarian cancer. 11531284 2001
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE The gene of phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) has been implicated as an oncogene in ovarian cancer [L. Shayesteh et al., Nat.Genet., 21: 99-102, 1999]. 12874030 2003
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Our study is the first direct evidence that PIK3CA is an oncogene in ovarian cancer and greatly extends recent findings in breast cancer. 15520168 2004
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease LHGDN PIK3CA mutations in ovarian cancer. 16203798 2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 CausalMutation disease CLINVAR Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. 15647370 2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease BEFREE Sequence mutations and gene amplifications lead to activation of the PIK3CA-AKT2 signaling pathway and have been reported in several types of neoplasms including ovarian cancer. 16721043 2006
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE The phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been strongly implicated in the genesis of ovarian cancer. 17178867 2006
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE This study aimed to identify secreted proteins regulated by the PI3K pathway in ovarian cancer cell lines. 16452192 2006
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 CausalMutation disease CLINVAR PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. 16353168 2006
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Taken together, these data suggest that PTEN over-expression may represent a novel therapeutic approach for chemoresistant human ovarian cancer and that this may involve a p53-mediated apoptotic cascade independent of the PI3K/Akt pathway. 16545436 2006
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease LHGDN Gain and/or amplification of PIK3CA gene, encoding the catalytic subunit of phosphatidylinositol 3-kinase (p110 alpha) and its increased expression are associated with enhanced PI3K activity in ovarian cancer cell lines. 17377809 2007
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 AlteredExpression disease BEFREE Prognostic value of PIK3CA and phosphorylated AKT expression in ovarian cancer. 17377809 2007
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 AlteredExpression disease LHGDN Taken together, our data demonstrate that IGF-I induces COX-2 expression in human ovarian cancer cells, which is mediated by three parallel signaling cascades--PI3K, MAPK, and PKC pathways that differentially regulate COX-2 expression at transcriptional and post-transcriptional levels. 17341442 2007
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 AlteredExpression disease BEFREE Transcriptional regulation of PIK3CA oncogene by NF-kappaB in ovarian cancer microenvironment. 18335034 2008
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 AlteredExpression disease BEFREE The demonstration that p53 binds directly to the PIK3CA promoter and inhibits its activity identifies a novel mechanism whereby these two mediators regulate cellular functions, and whereby inactivation of p53 and subsequent upregulation of PIK3CA might contribute to the pathophysiology of ovarian cancer. 18270270 2008
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 CausalMutation disease CLINVAR PIK3CA-activating mutations and chemotherapy sensitivity in stage II-III breast cancer. 18371219 2008
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 CausalMutation disease CLINVAR PIK3CA mutation associates with improved outcome in breast cancer. 19671852 2009
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE Our in vivo data suggests that PIK3CA activation is one of the early genetic events in ovarian cancer. 19172191 2009
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 GeneticVariation disease BEFREE PIK3CA gene encoding a catalytic subunit of the PI3K is mutated and/or amplified in various neoplasms, including ovarian cancer. 19029838 2009
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker disease BEFREE We found no evidence of disease association for SNPs in BRAF, KRAS, ERBB2 and PIK3CA when OC was considered as a single disease phenotype; but after stratification by histological subtype, we found borderline evidence of association for SNPs in KRAS and BRAF with mucinous OC and in ERBB2 and PIK3CA with endometrioid OC. 19240718 2009