Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 Biomarker disease BEFREE Our study indicated that Chk2 and p27 were vital anticancer targets of TF3 and provided more evidence that TF3 might be a potent agent to be applied as adjuvant treatment for ovarian cancer. 30769778 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 GeneticVariation disease BEFREE We analyzed germline CHEK2 variants in 1,928 high-risk Czech breast/ovarian cancer (BC/OC) patients and 3,360 population-matched controls (PMCs). 31050813 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 GeneticVariation disease BEFREE In this study, we have genotyped 68 MBC patients for the known breast or ovarian cancer associated mutations in the Finnish population in CHEK2, PALB2, RAD51C, RAD51D, and FANCM genes. 28874143 2017
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 Biomarker disease BEFREE The recent approval of three different PARP inhibitors for the treatment of ovarian cancer provides the impetus for further developing targeted inhibitors of many of the kinases involved in the DDR, including inhibitors of ATR, ATM, CHEK1, CHEK2, DNAPK and WEE1. 28984489 2017
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 Biomarker disease BEFREE Chk2-depleted ovarian cancer cell lines have diminished platinum sensitivity, suggesting that Chk2 should not be considered a therapeutic target along with platinum-based treatment in HGSOC patients. 24657486 2014
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 GeneticVariation disease BEFREE Our findings suggest that CHEK2 mutations may not contribute significantly to breast/ovarian cancer risk in Pakistani women. 23806170 2013
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 GeneticVariation disease BEFREE We discussed the potential application of CHEK2 variants in the evaluation of breast and ovarian cancer predisposition. 21120647 2011
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 GeneticVariation disease BEFREE These data indicate that CHEK2 variants may predispose to a range of ovarian tumor types of low malignant potential, but not to aggressive cancers. 16828850 2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 Biomarker disease BEFREE Twenty-three percent of ovarian tumors were negative for Chk2 protein by immunohistochemistry, but there was no significant correlation between LOH across the CHEK2 locus and intensity of Chk2 staining (P = 0.12). 17145815 2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 GeneticVariation disease BEFREE Between 2002-2005, probands from 300 US families with 4 or more cases of breast or ovarian cancer but with negative (wild-type) commercial genetic test results for BRCA1 and BRCA2 were screened by multiple DNA-based and RNA-based methods to detect genomic rearrangements in BRCA1 and BRCA2 and germline mutations of all classes in CHEK2, TP53, and PTEN. 16551709 2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 GeneticVariation disease BEFREE These results suggest that variations in CHEK2 do not make a significant contribution to the pathogenesis of OvCa in the U.S. population. 15385111 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 GeneticVariation disease BEFREE This is the first study from South India, on BRCA1, BRCA2 & CHEK2 (1100 del C) mutations in patients with a family history of breast and/or ovarian cancer and early onset breast/ovarian cancer, using the sensitive DHPLC approach. 14507240 2003
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 GeneticVariation disease LHGDN This is the first study from South India, on BRCA1, BRCA2 & CHEK2 (1100 del C) mutations in patients with a family history of breast and/or ovarian cancer and early onset breast/ovarian cancer, using the sensitive DHPLC approach. 14507240 2003
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 GeneticVariation disease BEFREE Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors. 11746983 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 Biomarker disease HPO
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.200 CausalMutation disease CLINVAR