Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE The present study was designed to evaluate the E2-independent effect of ERα/β on leptin-mediated cell invasion and cell proliferation in ovarian cancer. 31077012 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE The Evolution of Estrogen Receptor Signaling in the Progression of Endometriosis to Endometriosis-Associated Ovarian Cancer. 30302736 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Estrogen receptor (ER) positivity and progesterone receptor (PR) positivity were significant protective factors against subsequent BC and ovarian cancer. 29885789 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 PosttranslationalModification disease BEFREE Our results indicate a correlation between the presence of ESR1 methylation and a better clinical outcome in HGSC patients. 29807696 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Ovarian cancer is a major gynaecological cancer with different subtypes and studies have suggested that estrogen receptor (ER) or progesterone receptor (PR) positivity are associated with better clinical outcomes. 29137401 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Active Estrogen Receptor-alpha Signaling in Ovarian Cancer Models and Clinical Specimens. 28073843 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Immunohistochemical significance of ER alpha, inhibin A, calretinin, and Ki67 expression in granulosa cell ovarian tumors. 29250651 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE Differential expression of estrogen receptor subtypes and variants in ovarian cancer: effects on cell invasion, proliferation and prognosis. 28859612 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE This study uses primary cultures of mouse ovarian surface epithelium (OSE) to demonstrate that one possible mechanism by which estrogen accelerates the initiation of ovarian cancer is by up-regulation of microRNA-378 via the ESR1 pathway to result in the down-regulation of a tumour suppressor called Disabled-2 (Dab2). 29196616 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. 28376175 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE Expression of ER (Hazard Ratio (HR) = 0.18, 95% confidence interval 0.08-0.42, <i>p</i> = 0.0002) and of PR (HR = 0.22, 95% confidence interval 0.10-0.53, <i>p</i> = 0.0011) were significantly associated with longer ovarian cancer specific survival adjusted for age, grade, treatment center, stage, and residual disease. 28264438 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE Conversely, estrogen receptor signaling downregulates miR-486-5p and upregulates OLFM4 expression, slowing the development and progression of ovarian cancer. 26871282 2016
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Accordingly, immunohistochemical analysis of ERα-negative tissue specimens from HGSOC patients showed a significantly greater TAM infiltration in premenopausal compared to postmenopausal women. 26797759 2016
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ovarian cancer in mice. 24410765 2014
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Expression and clinical significance of estrogen-regulated long non-coding RNAs in estrogen receptor α-positive ovarian cancer progression. 24481591 2014
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Thus, miR-206 may be a promising candidate for the endocrine therapy of ERα-positive ovarian cancer. 24604205 2014
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE This growth promoting effect of OC cell growth was mediated by miR-26a inhibition of the posttranscription of ER-α. 24466274 2014
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE Our results demonstrate that PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERα and ERβ expression. 24376209 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE In the present study, estrogen receptor α (ERα)-negative/GPER-positive OVCAR5 ovarian cancer cell line was used to investigate the role of GPER in the migration and invasion of ovarian cancer. 23580092 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE Despite estrogen receptor (ER) expression in 67% of OVCAs, small anti-estrogen therapy trials have been disappointing and the benefit of hormonal therapy has not been systematically studied in large well-designed trials. 23402742 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE There was significant enrichment of ESR1 binding present in multiple datasets near genomic regions associated with breast cancer (7.45-fold, p = 0.001), height (2.45-fold, p = 0.002), multiple sclerosis (5.97-fold, p < 0.0002) and prostate cancer (4.47-fold, p = 0.0008), and suggestive evidence of ESR1 enrichment for regions associated with coronary artery disease, ovarian cancer, Parkinson's disease, polycystic ovarian syndrome and testicular cancer. 24171864 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 GeneticVariation disease BEFREE 19p13.1 and ZNF365 are susceptibility loci for ovarian cancer and ER subtypes of breast cancer among BRCA1 and BRCA2 mutation carriers. 22351618 2012
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Meanwhile, the at-risk A allele was positively related with the occurrence of mucinous ovarian cancer (OR = 3.48; 95% CI:1.15-6.83; P = 0.001), low degree of differentiation (OR = 1.87; 95% CI:1.03-3.47; P = 0.003), lymph node metastasis (OR = 1.69; 95% CI: 1.14-2.75; P = 0.010) and estrogen receptor positive (OR = 2.72; 95% CI: 1.38-4.81; P = 0.002). 23095717 2012
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 GeneticVariation disease BEFREE A SNP 19 kb downstream of ESR1 (rs2295190, G-to-T change) was associated with invasive ovarian cancer risk, with a per-T-allele odds ratio (OR) of 1.24 [95% confidence interval (CI), 1.06-1.44, P = 0.006]. rs2295190 is a nonsynonymous coding SNP in a neighboring gene called spectrin repeat containing, nuclear envelope 1 (SYNE1), which is involved in nuclear organization and structural integrity, function of the Golgi apparatus, and cytokinesis. 20056644 2010
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE To study a potential role of estrogen receptor-alpha gene amplification for estrogen receptor overexpression in ovarian cancer, a tumor tissue microarray containing 428 ovarian cancers was analyzed by fluorescence in situ hybridization for estrogen receptor-alpha gene amplification and immunohistochemistry for estrogen receptor expression. 18690166 2009