Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 CausalMutation disease CLINVAR A systematic approach to assessing the clinical significance of genetic variants. 24033266 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 Biomarker disease BEFREE Targeting PI3K and mTOR simultaneously using NVP-BEZ235 effectively inhibits ovarian cancer cell growth even in the presence of platinum resistance and prolongs survival of mice with intra-abdominal ovarian tumor disease. 21372221 2011
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 Biomarker disease BEFREE Copy number analysis using array Comparative Genomic Hybridization (aCGH) on 93 primary ovarian tumors identified PI3K/AKT pathway as the most frequently altered cancer related pathway. 21563232 2011
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 CausalMutation disease CLINVAR Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer. 20177704 2010
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 CausalMutation disease CLINVAR PIK3CA mutation associates with improved outcome in breast cancer. 19671852 2009
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 CausalMutation disease CLINVAR PIK3CA-activating mutations and chemotherapy sensitivity in stage II-III breast cancer. 18371219 2008
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 CausalMutation disease CLINVAR PIK3CA exon 20 mutation is independently associated with a poor prognosis in breast cancer patients. 18183466 2008
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 AlteredExpression disease LHGDN These data demonstrate that IGF-I induces COX-2 expression in human ovarian cancer cells, which is mediated by three parallel signaling cascades--PI3K, MAPK, and PKC pathways that differentially regulate COX-2 expression. 17341442 2007
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 Biomarker disease LHGDN PIK3CA amplification and Ki-67 index were strong predictors for an early tumor-associated death in ovarian cancer patients. 17377809 2007
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 AlteredExpression disease BEFREE We found that p110alpha downregulation greatly decreased ovarian tumor growth and angiogenesis, and that p110alpha siRNA inhibited VEGF expression through decreasing hypoxia-inducible factor 1alpha expression in both ovarian cancer cells and tumor tissues. 16775835 2006
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 CausalMutation disease CLINVAR PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. 16353168 2006
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 GeneticVariation disease LHGDN analysis of PIK3CA mutations in ovarian cancer [letter] 16203798 2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 CausalMutation disease CLINVAR Mutation of the PIK3CA gene in ovarian and breast cancer. 15520168 2004
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 CausalMutation disease CLINVAR High frequency of mutations of the PIK3CA gene in human cancers. 15016963 2004
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 AlteredExpression disease BEFREE We have used single-strand conformational polymorphism/heteroduplex analysis to demonstrate the presence of somatic mutations in the gene for the p85alpha regulatory subunit of PI3k (PIK3R1) in primary human colon and ovarian tumors and cancer cell lines. 11606375 2001
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 CausalMutation disease CGI
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.670 Biomarker disease CTD_human