Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE L-THP suppressed the expression of miR-93 and increased the levels of PTEN, a crucial tumor suppressor in OC. 31128026 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Notably, the results of dual-luciferase reporter assays indicated that PTEN was a direct downstream target of miR-19b in OC. 29963131 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE <i>miR-216a</i> up-regulation is associated with cisplatin resistance in ovarian cancer and this effect is mediated by PTEN. 30061175 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Overall, we suggest that miR-205 functions as an oncogenic miRNA by directly binding to SMAD4 and PTEN, providing a novel target for the molecular treatment of ovarian cancer. 28145479 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Upregulation of microRNA-18b induces phosphatase and tensin homolog to accelerate the migration and invasion abilities of ovarian cancer. 29142608 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE The OC tissues exhibited an increased expression of miR-214 and a reduced positive rate of PTEN expression compared with adjacent normal tissues. miR-214 may activate the PI3K/Akt signaling pathway by downregulating the targeted PTEN, which may promote OC cell proliferation and inhibit apoptosis. 29113199 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. 26212011 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE These data indicate that although PTEN mutations in ovarian cancer are rare, PTEN inhibition results in therapeutic sensitization. 26905328 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Subcutaneously transplanted nude mice, as a model of human ovarian cancer, were used to test the effects of PTEN and KRT10 on cisplatin resistance of ovarian cancer in vivo. 26125866 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE PTEN, a tumor suppressor gene, has been demonstrated to be able to reverse cisplatin-resistance in ovarian cancer cell line C13K. 24434152 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease CTD_human Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma. 21372221 2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE Furthermore, we demonstrated that knockdown of miR-21 significantly increased the expression of PTEN, a known tumor suppressor in ovarian cancer. 21042775 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 CausalMutation disease CLINVAR The PI3K pathway as drug target in human cancer. 20085938 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 CausalMutation disease CLINVAR PTEN and the PI3-kinase pathway in cancer. 18767981 2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE These findings indicate that deregulation of miRNAs is a recurrent event in human ovarian cancer and that miR-214 induces cell survival and cisplatin resistance primarily through targeting the PTEN/Akt pathway. 18199536 2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE BRCA1 and BRCA2 mutations confer very high risks of breast and ovarian cancer. p53 and PTEN mutations lead to very high breast cancer risks associated with rare cancer syndromes. 17292821 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease LHGDN MMAC tumor supressor gene expression in ovarian endometriosis and ovarian adenocarcinoma. 17713092 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE We aimed to evaluate frequency of PTEN mutation, LOH and expression in ovarian tumors. 16793127 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE Between 2002-2005, probands from 300 US families with 4 or more cases of breast or ovarian cancer but with negative (wild-type) commercial genetic test results for BRCA1 and BRCA2 were screened by multiple DNA-based and RNA-based methods to detect genomic rearrangements in BRCA1 and BRCA2 and germline mutations of all classes in CHEK2, TP53, and PTEN. 16551709 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE Taken together, these data suggest that PTEN over-expression may represent a novel therapeutic approach for chemoresistant human ovarian cancer and that this may involve a p53-mediated apoptotic cascade independent of the PI3K/Akt pathway. 16545436 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE We identified a frequency of molecular alterations in both independent and metastatic tumors, including microsatellite instability (uterine tumors, 50% and 67%, respectively; ovarian tumors, 33% and 67%) and PTEN mutations (uterine tumors, 38% and 100%; ovarian tumors, 33% and 83%) that is higher than that observed in single sporadic tumors. 16021566 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 PosttranslationalModification disease BEFREE This study was performed to investigate the hypermethylation status of the PTEN gene in ovarian cancer. 15072831 2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE It is for the purpose of this study to investigate its function and the mechanisms by which PTEN enhances the sensitivity of ovarian cancer to antitumor agents. 12006545 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE PTEN, a tumor suppressor commonly mutated (50%) in endometrial carcinoma, is found mutated in endometrioid carcinoma of the ovary, but not in other forms of ovarian cancer. 11949955 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 CausalMutation disease CLINVAR Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. 11504908 2001