Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE The objective of this study was to describe analytical performance characterization of the AmpliChip p53 Research Test to detect p53 mutations in genomic DNA isolated from archival FFPE human ovarian tumor tissues. 26125596 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE However, 4 of the 7 purely endometrioid ovarian tumors (57%) harbored a p53 mutation. 27016236 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE A more detailed analysis of these somatic mutations revealed a set of genes that are mutated in human BRCA2 mutant breast and ovarian tumours and that are also mutated in mouse Brca2-null, Trp53-null mammary tumours. 25692405 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Since mutations in TP53 occur in nearly all ovarian tumors, the objective of this study was to determine the relationship of oncomorphic TP53 mutations with patient outcomes in advanced serous ovarian cancer patients. 25385265 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE However, it is clear that mutations in the tumor suppressor gene TP53, which occur in 96% of serous ovarian tumors, alter the core molecular pathways involved in drug response. 24065105 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE In one extreme case, we identified two independent TP53 mutations in ovary tumors and omentum/peritoneum metastases, respectively. 24221193 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Exome sequencing of 12 primary mucinous ovarian tumours identified RNF43 as the most frequently somatically mutated novel gene, secondary to KRAS and mutated at a frequency equal to that of TP53 and BRAF. 23096461 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Since the p53 pathway controls autophagy, we investigated whether p53 regulates UPS in ovarian tumour cell lines. 20153923 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease LHGDN Prognosis of patients with p53-overexpressing ovarian cancer is affected by the MHC class I status of tumour cells and ovarian cancer patients can generate immune responses to the p53 tumour antigen. 18571704 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutation. 18234966 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Aberrant HRM curves indicative of TP53 mutations were observed for each of the samples in the ovarian tumour DNA panel. 17764544 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease LHGDN p53 appears to regulate EphA2 expression and clinical outcome in ovarian cancer. 16969087 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease LHGDN High frequency of BRCA1/2 and p53 somatic inactivation in sporadic ovarian cancer. 17968145 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease LHGDN impact of TP53 mutations and codon 72 genotype on survival of ovarian cancer patients 17488735 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease LHGDN p53 expression is not an independent prognostic predictor of progression-free survival or overall survival in ovarian cancer. 16880779 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Thirty-five (28%) ovarian tumors were found to contain one or more p53 variations, two of which were considered polymorphisms. 16183105 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease LHGDN Cyclin D1, p53, and p21Waf1/Cip1 have roles in progression of serous epithelial ovarian cancer 15297421 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease LHGDN p53 function was lost by TP53 germline mutation with the loss of a wild type allele induced by the chemotherapy against ovarian cancer, leading to the development of MDS. 15942101 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease LHGDN Results suggested that the loss of p53 expression in conjunction with the overexpression of p21 (WAF1/CIP1) was a stronger predictor of survival benefit than either molecule alone in Japanese serous-type advanced ovarian cancer. 16012716 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE In conclusion, adenoviral p53 gene transfer significantly increased the sensitivity of ovarian tumor cells to paclitaxel, to carboplatin and/or to the combination of both. 15153938 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Mutational spectrum of p53 mutations in primary breast and ovarian tumors. 15501075 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE To determine whether genetic abnormalities present in primary ovarian tumors can be used to detect cancer cells in peritoneal fluid, we tested 14 ovarian cancers and 1 benign tumor of the ovary for loss of heterozygosity (LOH) at chromosomal arms 13q, 17p, 17q, and 22q and for mutations in the p53 and K-ras genes. 12861058 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE At higher doses, differences between the TP53-mutated lines were observed with TOV-112D being less sensitive to cisplatin than OV-90 that also harbors a CDNK2A mutation. 15258697 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease LHGDN Alterations in p53 are a common event in advanced epithelial ovarian cancer/mutation in p53, but not overexpression of p53, is associated with a short-term survival benefit. 14551300 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease LHGDN p53 is an important mediators of chemoresistance in ovarian cancer cells. 14612499 2003