Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 GeneticVariation disease BEFREE These findings suggest that novel missense variants within the helicase domain of BRIP1 may confer risk for both breast and ovarian cancer and highlight the importance of functional testing for additional variants. 31822495 2020
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer. 29368626 2018
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 GeneticVariation disease BEFREE Based on the negative association between BRIP1 LoF mutations and familial BC in the absence of an OC family history, we conclude that the elevated mutation prevalence in the latter cohort was driven by the occurrence of OC in these families. 29368626 2018
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 Biomarker disease BEFREE Population-based BRCA1/BRCA2/RAD51C/RAD51D/BRIP1/PALB2 testing can prevent 1.86%/1.91% of BC and 3.2%/4.88% of OC in UK/US women: 657/655 OC cases and 2420/2386 BC cases prevented per million. 29361001 2018
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 GeneticVariation disease CLINVAR BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer. 29368626 2018
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer. 28423363 2017
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR Multigene panels in Ashkenazi Jewish patients yield high rates of actionable mutations in multiple non-BRCA cancer-associated genes. 28495237 2017
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR Panel Testing for Familial Breast Cancer: Calibrating the Tension Between Research and Clinical Care. 26786923 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 GeneticVariation disease CLINVAR Inherited Mutations in Women With Ovarian Carcinoma. 26720728 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 GeneticVariation disease BEFREE Aberrations in BRIP1 have been mainly associated with the development of breast cancer (BC), ovarian cancer, and type J Fanconi anemia. 26709662 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 GeneticVariation disease CLINVAR Germline multi-gene hereditary cancer panel testing in an unselected endometrial cancer cohort. 27443514 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing. 26921362 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 GeneticVariation disease CLINVAR Improving performance of multigene panels for genomic analysis of cancer predisposition. 26845104 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR Improving performance of multigene panels for genomic analysis of cancer predisposition. 26845104 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 GeneticVariation disease CLINVAR No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing. 26921362 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 GeneticVariation disease CLINVAR Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer. 27153395 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 GeneticVariation disease CLINVAR Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. 26681312 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR The Fanconi anemia DNA damage repair pathway in the spotlight for germline predisposition to colorectal cancer. 27165003 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR Genetic testing in a cohort of young patients with HER2-amplified breast cancer. 26681682 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR Inherited Mutations in Women With Ovarian Carcinoma. 26720728 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 GeneticVariation disease CLINVAR Monogenic and polygenic determinants of sarcoma risk: an international genetic study. 27498913 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer. 26976419 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. 26681312 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR Patterns and functional implications of rare germline variants across 12 cancer types. 26689913 2015
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.490 CausalMutation disease CLINVAR Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer. 26315354 2015