Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.040 Biomarker phenotype BEFREE The literature suggests that HHcy promotes TLR-4-driven chronic vascular inflammation and mitochondria-mediated cell death inducing peripheral vascular remodeling. 28386844 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.040 Biomarker phenotype BEFREE Toll-like receptor 4 (TLR4) plays critical roles in vascular inflammation, lipid accumulation and atherosclerosis development. 27807703 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.040 Biomarker phenotype BEFREE These findings identify the TLR4 signaling pathway as a key mediator of the deleterious effects of palmitate on endothelial NO signaling, and are the first to document a key role for TLR4 in the mechanism whereby diet-induced obesity induces vascular inflammation and insulin resistance. 17478729 2007
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.040 AlteredExpression phenotype BEFREE These findings suggest that NADPH oxidase activation, mRNA stabilization, and MAPK signaling pathways play critical roles in LPS-enhanced TLR4 expression in HASMCs, which contributes to vascular inflammation and cardiovascular disorders. 17008589 2006