Treatment with PJ34 improved rt-PA-induced reperfusion and promoted vascular protection including reduction in vascular inflammation (decrease in VCAM-1 expression), HT, and MCA vasospasm.
Nucleotide P2Y<sub>2</sub> receptor (P2Y<sub>2</sub>R) contributes to vascular inflammation by increasing vascular cell adhesion molecule-1 expression in endothelial cells (EC), and global P2Y<sub>2</sub>R deficiency prevents fatty streak formation in apolipoprotein E null (ApoE<sup>-/-</sup>) mice.