Our results not only demonstrated potential interactions of APOE epsilon2/epsilon3/epsilon4 and LDLRC1773T polymorphisms with risk of having ischemic stroke, but also added the evidence of independent role of hypertension and APOE epsilon2/epsilon3/epsilon4 polymorphism in the development of this disorder in Northern Han Chinese.
Using human-like genetically engineered hamsters, our findings demonstrated that both high LDL-C level caused by homozygous LDLR deficiency and severe low HDL-C level caused by deleting ABCA1 were risk factors of IS.
In binary logistic regression analysis of total studied population, ischemic stroke was observed significantly associated with LDLRrs688 both addictive model (TT/CC, adjusted OR = 1.47, 95% CI = 1.04-2.07) and recessive model (TT/CT + CC, adjusted Odds ratio (OR) = 2.66, 95% Confidence Interval (CI) = 1.37-5.14).
LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: towards pre-clinical simulation of symptomatic ICH.