×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population.
22462493
2013
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
GeneticVariation
disease
CLINVAR
A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.
23700264
2013
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Distinguishing hypertrophic cardiomyopathy-associated mutations from background genetic noise.
24510615
2014
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Multiplexed Reference Materials as Controls for Diagnostic Next-Generation Sequencing: A Pilot Investigating Applications for Hypertrophic Cardiomyopathy.
27639548
2016
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies.
25548289
2015
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility.
9245729
1997
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity.
23539503
2013
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Targeted next-generation sequencing helps to decipher the genetic and phenotypic heterogeneity of hypertrophic cardiomyopathy.
27600940
2016
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Deep basal inferoseptal crypts occur more commonly in patients with hypertrophic cardiomyopathy due to disease-causing myofilament mutations.
23771913
2013
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
GeneticVariation
disease
BEFREE
The familial hypertrophic cardiomyopathy mutation αTm E180G enhances Ca(2+)-sensitivity in functional assays.
22958892
2012
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
GeneticVariation
disease
BEFREE
Cardiac α-tropomyosin (Tm ) single-site mutations D175N and E180G cause familial hypertrophic cardiomyopathy (FHC).
22794249
2012
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
An epidemiologic investigation of physical activity and breast cancer risk in Africa.
25242052
2014
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples.
27532257
2017
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Genetic variations of α-cardiac actin and cardiac muscle LIM protein in hypertrophic cardiomyopathy in South India.
23204897
2012
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
"Clinical features of hypertrophic cardiomyopathy caused by mutation of a ""hot spot"" in the alpha-tropomyosin gene."
9060904
1997
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
Biomarker
disease
CTD_human
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy.
9241277
1997
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Development and validation of a computational method for assessment of missense variants in hypertrophic cardiomyopathy.
21310275
2011
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy.
22112859
2012
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
GeneticVariation
disease
BEFREE
Cardiac samples from patients with HCM harboring mutations in genes encoding thick (MYH7, MYBPC3) and thin (TNNT2, TNNI3, TPM1 ) filament proteins were compared with sarcomere mutation-negative HCM and nonfailing donors.
23508784
2013
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations.
21835320
2011
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Clinical phenotype and outcome of hypertrophic cardiomyopathy associated with thin-filament gene mutations.
25524337
2014
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy.
18533079
2008
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
GeneticVariation
disease
BEFREE
We studied the clinical and genetic features of familial hypertrophic cardiomyopathy (FHC) caused by an Asp175Asn mutation in the alpha-tropomyosin gene in affected subjects from three unrelated families.
9060904
1997
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
GeneticVariation
disease
BEFREE
Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy : a disease of the sarcomere.
8205619
1994
×
Entrez Id:
7168
Gene Symbol:
TPM1
TPM1
0.500
CausalMutation
disease
CLINVAR
A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.
23700264
2013