The lower expression of miR-134-5p was confirmed in primary airway fibroblasts from COPD patients with CMH.We identified miR-134-5p, miR-146a-5p and let-7 family, along with their potential target genes including <i>KRAS</i> and <i>EDN1</i>, as potential key miRNA-mRNA networks regulating CMH in COPD.