×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
Biomarker
disease
MGD
Gonadal effects of a mouse Denys-Drash syndrome mutation.
16245160
2005
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
UNIPROT
Identification of constitutional WT1 mutations, in patients with isolated diffuse mesangial sclerosis, and analysis of genotype/phenotype correlations by use of a computerized mutation database.
9529364
1998
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
UNIPROT
Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital development.
1302008
1992
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
BEFREE
Denys-Drash syndrome (DDS) is a well-known syndrome caused by several different germline mutations in the WT1 -gene.CDH in DDS is rare.
18203154
2008
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
UNIPROT
Molecular analysis of two Japanese cases of Denys-Drash syndrome.
8295405
1993
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
UNIPROT
Novel WT1 exon 9 mutation (D396Y) in a patient with early onset Denys Drash syndrome.
10738002
2000
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
BEFREE
Analysis of exons 2-10 of the WT1 gene in constitutional DNA from five patients with DDS was carried out using the polymerase chain reaction (PCR) and direct DNA sequencing.
8112732
1994
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
UNIPROT
In ten independent cases of Denys-Drash syndrome , point mutations in the zinc finger domains of one WT1 gene copy were found.
1655284
1991
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
CausalMutation
disease
CLINVAR
Genetic screening in adolescents with steroid-resistant nephrotic syndrome.
23515051
2013
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
UNIPROT
Evidence that WT1 mutations in Denys-Drash syndrome patients may act in a dominant-negative fashion.
8388765
1993
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
Biomarker
disease
BEFREE
DNA binding capacity of the WT1 protein is abolished by Denys-Drash syndrome WT1 point mutations.
7795587
1995
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
BEFREE
This report describes a novel WT1 gene mutation in a DDS patient.
20562648
2010
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
BEFREE
Constitutional mutations in the WT1 gene in patients with Denys-Drash syndrome .
1338906
1992
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
CausalMutation
disease
CLINVAR
Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital development.
1302008
1992
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
Biomarker
disease
GENOMICS_ENGLAND
The mutations found in our cases occurred in the same exon of the WT1 gene as detected in Denys-Drash syndrome (DDS ) and could not be explained by the previously proposed mechanism.
10571943
1999
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
Biomarker
disease
GENOMICS_ENGLAND
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
BEFREE
Patients with Denys-Drash syndrome (DDS ) have been shown to be constitutionally heterozygous for mutations of the WT1 gene.
9168922
1997
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
Biomarker
disease
MGD
A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome.
10077614
1999
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
Biomarker
disease
MGD
The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome.
15509792
2004
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
CausalMutation
disease
CLINVAR
Clinical pictures and novel mutations of WT1-associated Denys-Drash syndrome in two Chinese children.
21851196
2011
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
BEFREE
The WT1 gene is normally expressed during gonadal development and specific mutations in heterozygous form cause Drash syndrome , characterized by male pseudohermaphroditism and gonadal dysgenesis, renal failure and a predisposition for Wilms' tumour.
7607640
1995
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
CausalMutation
disease
CLINVAR
Twenty-four new cases of WT1 germline mutations and review of the literature: genotype/phenotype correlations for Wilms tumor development.
15150775
2004
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
UNIPROT
Constitutional WT1 correlate with clinical features in children with progressive nephropathy.
11182928
2000
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
UNIPROT
Constitutional mutations in the WT1 gene in patients with Denys-Drash syndrome .
1338906
1992
×
Entrez Id:
7490
Gene Symbol:
WT1
WT1
1.000
GeneticVariation
disease
BEFREE
Mutations in the donor splice site in intron 9 of the Wilms' tumor (WT1 ) gene have been shown to cause Frasier syndrome and are distinct from WT1 exon mutations associated with Denys-Drash syndrome .
10505699
1999