Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE The demonstration of elevated P-glycoprotein in ovarian carcinomas indicates that P-glycoprotein overexpression is not limited to experimental tumor models. 2653233 1989
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines. 2565764 1989
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE These results favor the expression of the MDR1 gene as one of the determinants involved in the acquired chemoresistance of ovarian cancers. 2766278 1989
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Although drug resistance is a major problem in treatment of ovarian cancer, resistance to the drugs most active against these tumors probably occurs through a mechanism other than expression of the MDR1 gene product. 1973872 1990
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE A large variability in P-gp expression and Topo I and II activity was observed in patients with ovarian cancer. 1682037 1991
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE The presence of even very low levels of MDR1 mRNA correlated with the lack of response to MDR regimens in these tumor types (P < .035 for ovarian carcinomas, P < .029 for SCLCs, and P < .0005 for both tumor types; Fisher's Exact Test). 1359152 1992
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE P-glycoprotein was positive on luminal surfaces of lining cells of ovarian cancer and on those of inclusion cysts from which epithelial ovarian cancer is considered to develop. 7509719 1994
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE A reduction in mdr-1 expression after 8-Cl-cAMP treatment was also observed in multidrug-resistant human ovarian cancer cell lines. 7543490 1995
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE The expression of the MDR1 gene has been shown to correlate with tumor aggressiveness and oncogenic activation both in experimental tumor models and in human clinical specimens In order to verify whether this association also takes place in ovarian carcinoma, we studied tumor samples from 39 patients by means of immunohistochemistry for the overexpression of P-glycoprotein (MDR1), nm23, c-erb-B2 and p53. 9216679 1997
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Co-expression of the MDR1 gene and HSP27 in human ovarian cancer. 9713493 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE To fill this gap, we investigated the rate of gene amplification of the mdr1-gene in 63 recurrent ovarian carcinomas and we determined the resistance pattern of these cells using an ex vivo assay. 10656626 1999
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE The ovarian carcinoma cell line SKOV3 transducted with a human multidrug resistance gene (mdr1) served as the drug resistant model (SKOV3/mdr1). 11780384 2001
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Caveolin-1 expression in ovarian carcinoma is MDR1 independent. 11863219 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Coinhibition of both Src and MDR-1 synergistically enhanced paclitaxel-induced cytotoxicity in paclitaxel-resistant ovarian cancer cell lines. 16288028 2005
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE The mdr-1 polymorphism G2677T/A in exon 21 correlates with the paclitaxel response in ovarian cancer and may be important for the function of P-glycoprotein and resistance to paclitaxel and provide useful information for individualized therapy. 16467099 2006
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE The drug concentrations applied referred to clinical relevant doses. mdr1 mRNA expression was significantly higher in specimens from recurrent ovarian cancer incubated in paclitaxel than in specimens from chemotherapy-naive ovarian cancer. 17001177 2006
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Paclitaxel, an antineoplastic agent used for the treatment of ovarian cancer, is metabolized by cytochrome P450 (CYP)3A4 and CYP2C8 and is excreted from cells by ATP-binding cassette (ABCB1) (multi-drug resistance [MDR1], P-glycoprotein). 16803472 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Knock-down of P-glycoprotein reverses taxol resistance in ovarian cancer multicellular spheroids. 17143487 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel. 17828752 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapy. 18765553 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE We therefore investigated the sensitivity of human ovarian carcinoma cells and their P-gp expressing MDR variants to complement. 19040611 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE Data regarding the prognostic value of ABCB1 gene polymorphisms in ovarian cancer patients is conflicting. 20944127 2010
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE The expression levels of miR-27a and P-gp were up-regulated in paclitaxel-resistant ovarian cancer cell line A2780/Taxol as compared with its parental line A2780. 20624637 2010
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE The aim of this study was to evaluate the effect of a MDR1 targeted fiber-modified CRAd against chemotherapy resistant ovarian cancer. 21741695 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Our data point at IMP-1 and MDR1 as indicators for response to therapy, and at IMP-1 as a novel therapeutic target for overcoming multidrug resistance of ovarian cancer. 21618519 2012