| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | AlteredExpression | disease | BEFREE | SPARC mRNA and protein expression was examined in 24 human invasive ovarian cancers, 5 tumors of low malignant potential (LMP), and 8 nonmalignant ovaries by in situ hybridization and immunohistochemistry. | 10502421 | 1999 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | The immunohistochemical data presented here confirmed the importance of diminished SPARC expression in ovarian cancer development. | 11485919 | 2001 | ||||
|
0.380 | Biomarker | disease | BEFREE | SPARC ameliorates ovarian cancer-associated inflammation. | 18813349 | 2008 | ||||
|
0.380 | Biomarker | disease | CTD_human | Addition of exogenous SPARC, as well as ectopic expression by an adenoviral vector, resulted in decreased proliferation of ovarian cancer cell lines. | 19177197 | 2009 | ||||
|
0.380 | PosttranslationalModification | disease | BEFREE | Aberrant promoter methylation of SPARC in ovarian cancer. | 19177197 | 2009 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | High SPARC expression was associated with high stage, low differentiation, lymph node metastasis and poor prognosis of ovarian cancer. | 22879971 | 2012 | ||||
|
0.380 | Biomarker | disease | BEFREE | These results suggest SPARC might function as a tumor suppressor inhibiting angiogenesis and lymphangiogenesis in ovarian cancer by reducing the expression of VEGF-C and VEGF-D. | 29075785 | 2017 | ||||
|
0.380 | Biomarker | disease | BEFREE | We used a syngeneic model of OvCa in <i>Sparc</i>-deficient and proficient mice to gain comprehensive insight into the paracrine effect of stromal-SPARC in metabolic programming of OvCa in the peritoneal milieu. | 30332737 | 2018 | ||||
|
0.380 | Biomarker | disease | BEFREE | These findings define a novel and functionally important role of SPARC in OvCa and not only bridge the knowledge gap but highlight the need to consider SPARC protein expression in therapeutic development. | 30765860 | 2019 |