Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation. 11329142 2001
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE beta-catenin mutation and expression analysis in ovarian cancer: exon 3 mutations and nuclear translocation in 16% of endometrioid tumours. 10417756 1999
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE We studied nine single nucleotide polymorphisms (SNPs) located in CTNNB1 (β-catenin) [rs4533622, rs2953], APC (rs11954856, rs351771, rs459552), and AXIN2 (rs4074947, rs7224837, rs3923087, rs2240308) in women with ovarian cancer without BRCA1/BRCA2 mutations (n = 228) and controls (n = 282). 24078348 2014
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE To summarize, the results of this study suggest that beta-catenin mutations and MI could represent two independent pathways in endometrioid ovarian carcinomas because they occur simultaneously very infrequently (in 5% of these cases). beta-catenin mutations are always associated with a nuclear beta-catenin expression pattern, whereas cases with a replication error -plus phenotype showed no abnormal beta-catenin subcellular localization. 11385321 2001
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas. 9537226 1998
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease UNIPROT Both nuclear and cytoplasmic beta-catenin expressions were demonstrated in 4 of the 27 ovarian carcinomas for which tissue samples were available for examination. 10391090 1999
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE Oncogenic activation of the Wnt signaling pathway is common in cancers, but mutation of beta-catenin in ovarian cancer is rare. 19957335 2010
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Exclusively, studies assessing epithelial OC or invasive epithelial OC with full-gene screening of both BRCA1 and BRCA2 mutations were evaluated. 26809252 2016
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Women with mutations in the BRCA1 or BRCA2 cancer susceptibility genes face unique choices regarding management of their high risk for breast and ovarian cancer that impact their reproductive options. 18026853 2008
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE These data are consistent with the hypothesis that BRCA1 mutations are involved in the etiology of hereditary ovarian carcinomas but occur rarely in sporadic tumors, and that the frequent allelic loss on chromosome 17q in this cancer type reflects the involvement of an additional tumor suppressor gene(s). 7606717 1995
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population. 24728189 2014
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE The used algorithm also allowed to identify healthy BRCA1 mutation carriers when compared to healthy wildtype women (sensitivity 88.4%, specificity 80.7%, AUC = 0.895; p = 6e-08), while this was less pronounced in patients with OC (sensitivity 66.7%, specificity 67.8%, AUC = 0.724; p = 0.00065). 29244844 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Characteristics and spectrum of BRCA1 and BRCA2 mutations in 3,922 Korean patients with breast and ovarian cancer. 22798144 2012
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE The spectrum of germline mutations among Jewish non Ashkenazi high risk breast/ovarian cancer families includes a few predominant mutations in BRCA1 (185delAG and Tyr978X) and BRCA2 (8765delAG). 22399190 2012
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE About 1% of the BC and OC Spanish families negative for BRCA1/BRCA2 are carriers of RAD51D mutations. 24130102 2014
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Germline mutations in the BRCA1 and BRCA2 genes have been shown to account for the majority of hereditary breast and ovarian cancers. 16168118 2005
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE BRCA1 and BRCA2 genes are responsible for 5-10% of breast and ovarian cancer cases. 16783967 2006
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Inherited or acquired defects in HR, such as mutations in breast cancer susceptibility protein-1 (BRCA1) or BRCA2, predispose to cancer, including breast and ovarian cancers. 29145865 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE BRCA1 germline mutations confer a high risk of early-onset breast and ovarian cancer. 22362584 2012
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE These results suggest that germline mutations of the BRCA1 gene play an important role in the carcinogenesis of breast and/or ovarian cancer in a majority of breast-ovarian cancer families and in some site-specific ovarian cancer families. 9197534 1997
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Individuals carrying BRCA2 mutations are predisposed to breast and ovarian cancers. 11239456 2001
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE BRCA1 and BRCA2 mutations were found in 8% (17 cases) and 3% (7 cases) of the ovarian cancer patients, respectively. 26541979 2016
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Among a cohort of women with BRCA1 and BRCA2 mutations, the use of risk-reducing mastectomy was associated with a lower risk of breast cancer; risk-reducing salpingo-oophorectomy was associated with a lower risk of ovarian cancer, first diagnosis of breast cancer, all-cause mortality, breast cancer-specific mortality, and ovarian cancer-specific mortality. 20810374 2010
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE DNA samples from 50 individuals affected with breast cancer from non-BRCA1/2 French Canadian families with a high risk of breast and ovarian cancer were screened for sequence variants in HSD17B1. 18083510 2008
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Women carrying a pathogenic mutation in either BRCA1 or BRCA2 have a major risk of developing breast and/or ovarian cancer. 19405878 2009