Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.030 AlteredExpression disease BEFREE Unconventional prefoldin RPB5 interactor (URI, or RMP, a member of the prefoldin family of molecular chaperones) exhibits oncogenic activity in several types of cancer, including ovarian cancer. 30662936 2019
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.030 Biomarker disease BEFREE ATP-binding cassette transporter A7 (ABCA7) is a candidate regulator of OC progression. 30333865 2018
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.030 GeneticVariation disease BEFREE Alternative splicing of the multidrug resistance protein 1/ATP binding cassette transporter subfamily gene in ovarian cancer creates functional splice variants and is associated with increased expression of the splicing factors PTB and SRp20. 15269137 2004
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
0.010 AlteredExpression disease BEFREE The expression of ABCA7 was higher in OC tissues than in adjacent noncancerous tissues. 30333865 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Indeed, treatment of OC cell lines with TNFα and IL6 induced a selective increase in the expression of TAP1 and multidrug resistance protein 1, whereas TAP1 silencing sensitized cells to cisplatin-induced apoptosis. 27206315 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE We therefore investigated the sensitivity of human ovarian carcinoma cells and their P-gp expressing MDR variants to complement. 19040611 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel. 17828752 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Co-expression of the MDR1 gene and HSP27 in human ovarian cancer. 9713493 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE The expression of the MDR1 gene has been shown to correlate with tumor aggressiveness and oncogenic activation both in experimental tumor models and in human clinical specimens In order to verify whether this association also takes place in ovarian carcinoma, we studied tumor samples from 39 patients by means of immunohistochemistry for the overexpression of P-glycoprotein (MDR1), nm23, c-erb-B2 and p53. 9216679 1997
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE Data regarding the prognostic value of ABCB1 gene polymorphisms in ovarian cancer patients is conflicting. 20944127 2010
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE The ovarian carcinoma cell line SKOV3 transducted with a human multidrug resistance gene (mdr1) served as the drug resistant model (SKOV3/mdr1). 11780384 2001
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE The goal of this study is to evaluate the ability of HA-PEI/HA-PEG to deliver MDR1 siRNA and the efficacy of the combination of HA-PEI/HA-PEG/MDR1 siRNA with paclitaxel to suppress growth of ovarian cancer. 25687880 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Coinhibition of both Src and MDR-1 synergistically enhanced paclitaxel-induced cytotoxicity in paclitaxel-resistant ovarian cancer cell lines. 16288028 2005
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE The mdr-1 polymorphism G2677T/A in exon 21 correlates with the paclitaxel response in ovarian cancer and may be important for the function of P-glycoprotein and resistance to paclitaxel and provide useful information for individualized therapy. 16467099 2006
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Polymorphisms of <i>ABCB1, CYP3A4</i> and <i>CYP3A5</i> Genes in Ovarian Cancer and Treatment Response in Poles. 29491071 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapy. 18765553 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE A large variability in P-gp expression and Topo I and II activity was observed in patients with ovarian cancer. 1682037 1991
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE The aim of this study was to evaluate the effect of a MDR1 targeted fiber-modified CRAd against chemotherapy resistant ovarian cancer. 21741695 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Our data point at IMP-1 and MDR1 as indicators for response to therapy, and at IMP-1 as a novel therapeutic target for overcoming multidrug resistance of ovarian cancer. 21618519 2012
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE The expression levels of miR-27a and P-gp were up-regulated in paclitaxel-resistant ovarian cancer cell line A2780/Taxol as compared with its parental line A2780. 20624637 2010
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE The inhibition of P-glycoprotein (P-gp) was determined in vitro, and the respective sensitization of doxorubicin-resistant ovarian carcinoma overproducing P-gp was detected. 31416138 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE P-glycoprotein was positive on luminal surfaces of lining cells of ovarian cancer and on those of inclusion cysts from which epithelial ovarian cancer is considered to develop. 7509719 1994
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE TUBB3, ERCC1 and P-gp are involved in the occurrence and development of ovarian cancer and can be used as important indexes judging the severity of ovarian cancer, providing a reference for the occurrence and development of the disease in ovarian cancer patients in clinical practice. 30570863 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE The drug concentrations applied referred to clinical relevant doses. mdr1 mRNA expression was significantly higher in specimens from recurrent ovarian cancer incubated in paclitaxel than in specimens from chemotherapy-naive ovarian cancer. 17001177 2006
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Hypermethylation of the analyzed ABCB1 promoter region was significantly correlated with low levels of the ABCB1 transcript in tumors from a subset of patients with breast and ovarian carcinoma prior to chemotherapy but not following treatment. 31173253 2019