Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Underestimation of risk of a BRCA1 or BRCA2 mutation in women with high-grade serous ovarian cancer by BRCAPRO: a multi-institution study. 24638001 2014
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE We also used this data set to estimate the age-specific risks for breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers. 16417652 2006
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Neither loss of heterozygosity (LOH) for BRCA1 nor mutations of the TP53 (also known as p53) gene have been documented prior to invasion in ovarian cancers arising in women with germline BRCA1 mutations. 10880552 2000
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE In conclusion, founder mutations in BRCA1 and BRCA2 contribute to up to one-third of the families in western Denmark and among these the BRCA1 c.3319G>T mutation is potentially linked to an increased risk of ovarian cancer. 26833046 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Next-generation sequencing of the BRCA1 and BRCA2 genes for the genetic diagnostics of hereditary breast and/or ovarian cancer. 25556971 2015
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Mutation screening for the 185delAG and the 5382insC mutations in BRCA1 and the 6174delT mutation in BRCA2 was performed on DNA samples from either subjects affected by breast or ovarian cancer or obligate gene carriers. 9475087 1998
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Germ-line mutations in BRCA1 and BRCA2 are responsible for an inherited predisposition of breast and ovarian cancer. 16825125 2006
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE <b>Purpose:</b> PARP inhibitors (PARPi) are primarily effective against BRCA1/2-mutated breast and ovarian cancers, but resistance due to reversion of mutated BRCA1/2 and other mechanisms is common. 29615458 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Our observations suggest that the total mutation burden coupled with BRCA1 or BRCA2 mutations in ovarian cancer is a genomic marker of prognosis and predictor of treatment response. 24265793 2013
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Bilateral prophylactic salpingo-oophorectomy (BPSO) is used widely used to reduce the risk of breast and ovarian cancer in women with BRCA1 and BRCA2 mutations. 16510331 2006
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE BRCA1 VUSs are frequently found in patients with hereditary breast or ovarian cancer and present a serious problem for clinical geneticists. 23867111 2013
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE The discovery that mutations in the BRCA1 and BRCA2 genes increase the risk of breast and ovarian cancers has radically transformed our understanding of the genetic basis of breast cancer, leading to improved management of high-risk women. 19088015 2008
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE The lifetime incidence of breast cancer in mutation carriers is above 50 percent, and carriers of BRCA1 mutation also have a substantially increased risk of ovarian cancer. 9917577 1999
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population-based series of early-onset breast cancer. 11504767 2001
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE BRCA1 is a tumor suppressor gene which is inactivated by mutation in familial breast and ovarian cancers. 17921118 2007
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE BRCA1 and BRCA2 mutations in breast and ovarian cancer syndrome: reflection on the Creighton University historical series of high risk families. 16528604 2006
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE The list of identified germline mutations in BRCA1 and BRCA2 is still growing, and mutation carriers have a substantial lifetime risk of both breast and ovarian cancer. 10369075 1999
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE The prevalence of BRCA1 or BRCA2 mutations among case subjects with breast cancer was 6.7% (95% confidence interval [CI] 4.1%-9.4%), and that among case subjects with ovarian cancer was 15.8% (95% CI 9.2%-22.4%). 12181777 2002
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Overall, 178/2192 (8.1%) evaluable OC women showed pathogenic germline mutations in BRCA genes (84 BRCA1;94 BRCA2). 31253107 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE We also used this data set to estimate the age-specific risks for breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers. 16417652 2006
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE The increased risk for ovarian cancer in BRCA2 related families were limited to the cases leading to mutation analysis. 10615237 1999
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Research on the utilization of genetic testing services for mutations in BRCA1 and BRCA2 has focused on women with a strong family history of breast and ovarian cancer. 15598789 2004
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Next-generation sequencing of the BRCA1 and BRCA2 genes for the genetic diagnostics of hereditary breast and/or ovarian cancer. 25556971 2015
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Usefulness of polymorphic markers in exclusion of BRCA1/BRCA2 mutations in families with aggregation of breast/ovarian cancers. 12923317 2003
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE The major areas on which recent reports have focused include: (1) an expanded understanding of the BRCA1 and BRCA2 mutation spectrum and the frequencies of deleterious alleles in various ethnic groups; (2) investigations on how information is best transmitted to high-risk family members via genetic counseling; (3) an analysis of patient management changes based on genotype results; (4) social issues surrounding predictive testing for breast/ovarian cancer genes, including health insurance and discrimination concerns; and (5) an investigation into gynecologists' knowledge of ovarian cancer genetics, and their ability to provide genetic counseling for ovarian cancer to their patients. 15128012 2004