Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | Epigenetic silencing of miR-130b in ovarian cancer promotes the development of multidrug resistance by targeting colony-stimulating factor 1. | 22005523 | 2012 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Elevated levels of CSF-1 promote progression of ovarian cancer, by binding to CSF-1R (the tyrosine kinase receptor encoded by c-fms proto-oncogene).Post-transcriptional regulation of CSF-1 mRNA by its 3' untranslated region (3'UTR) has been studied previously. | 22909061 | 2012 | ||||
|
0.090 | Biomarker | disease | BEFREE | These findings suggest the usefulness of M-CSF in diagnosing ovarian cancer, especially when discriminating between cancer and non-carcinoma lesions. | 22988839 | 2012 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Finally downstream target validation was proven for the miR-130a, whose downregulation was linked to the translational activation of the M-CSF gene, a known resistance factor for ovarian cancer. | 18823650 | 2008 | ||||
|
0.090 | Biomarker | disease | BEFREE | CSF-1 is strongly correlated with the poor prognosis of patients with ovarian cancer. | 18708368 | 2008 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | MDR human ovarian cancer (AD10) cells were transduced with the human M-CSF gene inserted into an expression vector to establish gene-modified cells capable of producing low (ML-AD10), intermediate (MM-AD10) nd high (MH-AD10) amounts of M-CSF. | 8698627 | 1996 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | The co-expression of M-CSF (CSF-1) and its receptor in specimens of ovarian cancer has recently been reported. | 7965406 | 1994 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | In addition, some proto-oncogenes such as the EGF receptor (erbB) and the M-CSF receptor (fms) are expressed along with their respective ligands in some ovarian cancers. | 1500387 | 1992 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Two of three human ovarian carcinoma cell-lines expressed multiple species of CSF-1 mRNA. | 2973787 | 1988 |