Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE Populations of endometrial and endometriotic epithelial cells also harbor multiple cancer driver mutations, such as KRAS, which may be associated with the establishment of pelvic endometriosis or ovarian cancer. 30994890 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE Preliminary evidence of clinical activity was observed with gedatolisib plus PD-0325901 in patients with ovarian cancer (three partial responses, n = 5) or endometrial cancer (one partial response, n = 1) and KRAS mutations. 29067643 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE Mutations in BRAF and KRAS genes are the most frequent genetic aberrations found in low-grade serous ovarian carcinomas and serous and mucinous borderline tumors. 28992761 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE VEGF concentrations in ascites significantly increased in c-MYC-induced ovarian cancer, whereas the concentrations of inflammatory cytokines in ascites were significantly high in KRAS-induced ovarian cancer and were accompanied by an increased number of neutrophils in ascites. 27483433 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE Reintroducing KRAS rescued the inhibitory effects exerted by miR-613 on ovarian cancer cell proliferation and invasion. 26631045 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE Our results define the RAS/MEK/DNMT1 pathway as a determinant of sensitivity to DNA methyltransferase inhibition, specifically implicating KRAS status as a biomarker of drug response in ovarian cancer. 25968887 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE Together, REDD1 and p-AKT over-expression may serve as a prognostic biomarker in OC, but KRAS mutations and REDD1 protein over-expression were not correlated in OC. 25337238 2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE The results from this study confirm previously demonstrated associations of KRAS mutations with well-differentiated and mucinous ovarian carcinomas. 23800114 2013
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE Additionally, RAS/RAF/MEK/ERK pathway-targeted therapy may benefit selected patients with type II ovarian carcinoma harboring KRAS/MAPK1 amplifications. 23820584 2013
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE The KRAS-variant is associated with risk of developing double primary breast and ovarian cancer. 22662244 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE An assay for the single-nucleotide polymorphism (SNP), rs61764370, has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'-UTR miRNA binding site of the KRAS oncogene and is a candidate for epithelial ovarian cancer (EOC) susceptibility. 21385923 2011
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease CTD_human Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma. 21372221 2011
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE Recently, a variant allele in the 3'UTR of the KRAS gene (rs61764370 T>G) was shown to be associated with an increased risk for developing non-small cell lung cancer, as well as ovarian cancer, and was most enriched in ovarian cancer patients from hereditary breast and ovarian cancer families. 20676756 2011
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE Our findings strongly support the hypothesis that the KRAS-variant is a genetic marker for increased risk of developing OC, and they suggest that the KRAS-variant may be a new genetic marker of cancer risk for HBOC families without other known genetic abnormalities. 20647319 2010
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE Mutations in the KRAS gene are one of the most frequent genetic abnormalities in ovarian carcinoma. 19358724 2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE We found no evidence of disease association for SNPs in BRAF, KRAS, ERBB2 and PIK3CA when OC was considered as a single disease phenotype; but after stratification by histological subtype, we found borderline evidence of association for SNPs in KRAS and BRAF with mucinous OC and in ERBB2 and PIK3CA with endometrioid OC. 19240718 2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE Next, to clarify the roles of ERK1/2 activation in ovarian cancers harbouring KRAS or BRAF mutations, we inactivated ERK1/2 in ovarian cancer cells using CI-1040. 19018267 2008
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE The apparent restriction of these BRAF and KRAS mutations to low-grade serous ovarian carcinoma and its precursors suggests that low-grade and high-grade ovarian serous carcinomas develop through independent pathways. 12644542 2003
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE Role of KRAS and BRAF gene mutations in mucinous ovarian carcinoma. 12893203 2003
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE Thus, K-RAS mutations at codon 12 and 6q27 LOH were suggested to be involved in the development and/or progression of mucinous ovarian carcinoma and serous ovarian carcinoma, respectively. 10748293 2000
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 AlteredExpression disease BEFREE This suggests that mutation of the nm23 genes and the K-ras gene affects carcinogenesis or progression of ovarian carcinoma by modulating expression of the nm23 genes. 7669582 1995
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE A cell line from a human ovarian carcinoma with amplification of the K-ras gene. 3756872 1986
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease HPO
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 CausalMutation disease CGI