| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | This study was designed to investigate the role and therapeutic potential of miR-34 in ovarian cancer. | 30905732 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | In addition, treatment with the miR-34a mimic partially recovered the cisplatin sensitivity of SKOV3cp cells, whereas HDAC1 overexpression blocked the above phenomena caused by treatment with the miR-34a mimic. miR-34a exhibited suppressive effects on OC cells via directly binding and downregulating HDAC1 expression, which subsequently decreased the resistance to cisplatin and suppressed proliferation in OC cells. | 29561664 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | In conclusion, our results suggest that the Lnc-OC1-miR-34a/34c axis may play a pivotal role in OC, and may serve as a potential diagnostic biomarker and a powerful therapeutic target for OC. | 29576507 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | In addition, NEAT1 was demonstrated to directly interact with miR-34a-5p and exert its oncogenic role in OC by negatively regulating miR-34a-5p. | 29062236 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | The inverse association between miR-34a expression and grading, p53 mutation status and dualistic tumor type classification, together with its prognostic relevance may underline the tumor-suppressive character of miR-34a in ovarian cancer. | 26879132 | 2016 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We report that OC tissues possess significantly decreased levels of miR-137 and miR-34a and increased expression of Snail when compared to their adjacent normal tissues, and lower miR-137 and miR-34a expression correlates with worse patient survival. | 27596137 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our data suggest that miR-34a may function as a tumor suppressor through repression of oncogenic AXL in ovarian cancer. | 25895459 | 2015 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Frequent downregulation of miR-34 family in human ovarian cancers. | 20145172 | 2010 |