Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
0.370 Biomarker disease BEFREE GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification. 26887977 2016
Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
0.370 Biomarker disease BEFREE Here, we designed small-scale siRNA screens targeting these six mesenchymal signature genes (CD99L2, EMP3, ITGA5, SYDE1, VIM, ZEB1) to explore their functional relevance and their roles during EMT reversal by nintedanib (BIBF1120) in a mesenchymal-like SKOV3 ovarian cancer cell line. 26061747 2016
Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
0.370 AlteredExpression disease BEFREE Forced ZEB1 expression abolished miR200-induced inhibition of ovarian cancer cell invasiveness, suggesting that ZEB1 is a direct target of miR200 for inhibiting ovarian cell invasiveness. 25119590 2015
Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
0.370 AlteredExpression disease BEFREE Overexpression of transcription factors SNAI1, TWIST1, and ZEB1, which regulate the epithelial-to-mesenchymal transition (EMT), promoted mesothelial clearance in cell lines with weak activity, while knockdown of the EMT-regulatory transcription factors TWIST1 and ZEB1 attenuated mesothelial clearance in ovarian cancer cell lines with strong activity. 24762435 2014
Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
0.370 AlteredExpression disease BEFREE This study demonstrates a novel mechanism in which FGF2 down-regulates E-cadherin expression through the activation of PI3K/Akt/mTOR and MAPK/ERK signaling, and the up-regulation of Slug and ZEB1 in human ovarian cancer cells. 23554977 2013
Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
0.370 AlteredExpression disease BEFREE Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: evidence supporting a mesothelial-to-epithelial transition. 19854497 2009
Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
0.370 Biomarker disease CTD_human Expression of the ZEB1 (deltaEF1) transcription factor in human: additional insights. 18622689 2008
Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
0.370 AlteredExpression disease BEFREE These findings were extended to primary ovarian cancer specimens. miR-200 was found to directly target the mRNA of the E-cadherin transcriptional repressors ZEB1 (TCF8/deltaEF1) and ZEB2 (SMAD-interacting protein 1 [SIP1]/ZFXH1B). 18381893 2008