Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 GeneticVariation disease BEFREE These findings suggest that novel missense variants within the helicase domain of BRIP1 may confer risk for both breast and ovarian cancer and highlight the importance of functional testing for additional variants. 31822495 2020
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 Biomarker disease BEFREE Population-based BRCA1/BRCA2/RAD51C/RAD51D/BRIP1/PALB2 testing can prevent 1.86%/1.91% of BC and 3.2%/4.88% of OC in UK/US women: 657/655 OC cases and 2420/2386 BC cases prevented per million. 29361001 2018
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 GeneticVariation disease BEFREE Based on the negative association between BRIP1 LoF mutations and familial BC in the absence of an OC family history, we conclude that the elevated mutation prevalence in the latter cohort was driven by the occurrence of OC in these families. 29368626 2018
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 Biomarker disease BEFREE Population panel testing for <i>BRCA1/BRCA2/RAD51C/RAD51D/BRIP1/PALB2</i> gene mutations is the most cost-effective genetic-testing strategy in general-population women and can prevent thousands more breast and ovarian cancers than current clinical-criteria based approaches. 30400647 2018
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 GeneticVariation disease BEFREE Aberrations in BRIP1 have been mainly associated with the development of breast cancer (BC), ovarian cancer, and type J Fanconi anemia. 26709662 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 GeneticVariation disease BEFREE We found an increased frequency of deleterious mutations in BRIP1 in case patients (0.9%) and in the UKFOCSS participants (0.6%) compared with control patients (0.09%) (P = 1 x 10(-4) and 8 x 10(-4), respectively), but no differences for BARD1 (P = .39), NBN1 ( P = .61), or PALB2 (P = .08). 26315354 2015
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 Biomarker disease BEFREE FANCJ is a DNA helicase that is genetically linked to Fanconi anemia, breast cancer, and ovarian cancer. 24573678 2014
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 GeneticVariation disease BEFREE Thirty-one percent of ovarian carcinomas had a deleterious germline (24%) and/or somatic (9%) mutation in one or more of the 13 homologous recombination genes: BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK1, CHEK2, FAM175A, MRE11A, NBN, PALB2, RAD51C, and RAD51D. 24240112 2014
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 Biomarker disease BEFREE Ovarian tumors from heterozygous carriers of the Icelandic mutation show loss of the wild-type allele, indicating that BRIP1 behaves like a classical tumor suppressor gene in ovarian cancer. 21964575 2011
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 Biomarker disease CTD_human Ovarian tumors from heterozygous carriers of the Icelandic mutation show loss of the wild-type allele, indicating that BRIP1 behaves like a classical tumor suppressor gene in ovarian cancer. 21964575 2011
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 GeneticVariation disease GWASDB Ovarian tumors from heterozygous carriers of the Icelandic mutation show loss of the wild-type allele, indicating that BRIP1 behaves like a classical tumor suppressor gene in ovarian cancer. 21964575 2011
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 GeneticVariation disease BEFREE Thus, common variants in the BRIP1 are candidates for breast and ovarian cancer susceptibility. 17342202 2007
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 GeneticVariation disease BEFREE FA proteins, including a ubiquitin ligase (FANCL), a monoubiquitinated protein (FANCD2), a helicase (FANCJ/BACH1/BRIP1), and a breast/ovarian cancer susceptibility protein (FANCD1/BRCA2), appear to cooperate in a pathway leading to the recognition and repair of damaged DNA. 16493006 2006
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 GeneticVariation disease UNIPROT
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.700 CausalMutation disease CLINVAR