Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE Our work also provides a proper understanding on the regulation of Wnt/β-catenin pathway in ovarian cancer. 30572097 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 AlteredExpression disease BEFREE Further, the expression of SOX9, β-catenin, and c-Myc in OC tissues was upregulated and inversely correlated with miR-34c expression, indicating that rescuing miR-34c expression, thus to inhibit SOX9, β-catenin, and c-Myc expression presents a promising strategy of reducing the chemoresistance of the OC cell to DDP. 30537410 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cancer by dephosphorylating and inactivating β-catenin. 31653698 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE Silencing LGR6 Attenuates Stemness and Chemoresistance via Inhibiting Wnt/β-Catenin Signaling in Ovarian Cancer. 31193124 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) promotes the EMT of serous ovarian cancer by activating the hexosamine biosynthetic pathway to increase the nuclear location of β-catenin. 31685298 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE These results suggested that miR-214 may serve as a tumor suppressor of ovarian cancer by targeting the β-catenin pathway. 29486472 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 AlteredExpression disease BEFREE Nucleus and/or cytoplasma of β-catenin expression might be associated with tumor progression and could be a possible potential predictive factor of poor prognosis in OC patients. 30103006 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE Our work highlights the therapeutic value of inhibiting Wnt/β-catenin in ovarian cancer. 28090074 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE Taken together, this study showed that Annexin A2 inhibition suppresses proliferation and invasion in ovarian cancer via β-catenin/EMT, proposing the potential role of Annexin A2 in the prevention and treatment of ovarian cancer. 28440436 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE These results uncover β-catenin as a critical factor in promoting ovarian cancer aggressiveness and a new mechanism linking between β-catenin and miRNA downregulation underlying this process. 28650464 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 AlteredExpression disease BEFREE Importantly, JRK expression was aberrantly elevated in 21% of colorectal cancers, 15% of breast and ovarian cancers and was associated with increased expression of β-catenin target genes and increased cell proliferation. 26455321 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancer. 26341496 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE Collectively, our results suggested for the first time that NGF is functionally linked to β-catenin in the migration of human ovarian cancer cells, which may be a novel therapeutic perspective to prevent the spread of ovarian carcinomas by studying the interaction between NGF/NGFRs and canonical WNT/β-catenin signaling. 27835587 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE Our study identifies activated Wnt signalling to be a marker for precursor lesions of OC and successfully develops a mouse model that mimics the earliest events in pathogenesis of OC by constitutively activating βcatenin. 27588493 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE β-Catenin knockdown blocked tumor growth and peritoneal metastasis in an OC xenograft model. 24954508 2015
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE Thus, β-catenin could be a potential therapeutic target for the therapy of cisplatin-resistant ovarian cancer. 25211326 2015
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE We studied nine single nucleotide polymorphisms (SNPs) located in CTNNB1 (β-catenin) [rs4533622, rs2953], APC (rs11954856, rs351771, rs459552), and AXIN2 (rs4074947, rs7224837, rs3923087, rs2240308) in women with ovarian cancer without BRCA1/BRCA2 mutations (n = 228) and controls (n = 282). 24078348 2014
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE Collectively, these data indicated that β-catenin is involved in Twist2-induced EMT in ovarian cancer. 24244294 2013
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway. 22232518 2012
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE CXC chemokine receptor 4 plays a critical role in the metastasis of human ovarian cancer possibly through modulating the Wnt/β-catenin pathway. 21738044 2011
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease CTD_human Effect of downregulated β-catenin on cell proliferative activity, the sensitivity to chemotherapy drug and tumorigenicity of ovarian cancer cells. 22000491 2011
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE Oncogenic activation of the Wnt signaling pathway is common in cancers, but mutation of beta-catenin in ovarian cancer is rare. 19957335 2010
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 AlteredExpression disease BEFREE In this study, the impact of beta-catenin expression on genomic instability in ovarian carcinoma, as determined by DNA ploidy, was investigated. 15911235 2005
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 AlteredExpression disease BEFREE Expression of E-cadherin and beta-catenin was positively correlated with DPPIV expression among five independent ovarian carcinoma cell lines. 12727850 2003
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation. 11329142 2001