Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE COX-2 Docking Structural Analysis with Phytochemical Extracts of Rosemary: A Possible Cytotoxicity on Head and Neck Squamous Cell Carcinoma Cell Line (HEp-2). 31244433 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Moreover, targeting COX-2 could be a promising strategy for the treatment of HNSCC. 27696591 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation disease BEFREE For unadjusted data, an association with increased risk was observed in three genetic models in COX-2 rs689466 polymorphism; however, COX-2 rs5275 and rs20417 polymorphisms were not related to HNSCC risk in this study. 27412115 2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation disease BEFREE CONCLUSIONS This meta-analysis indicated that COX-2 rs689466 polymorphism might be associated with increased susceptibility to HNSCC. 26568042 2015
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE We investigated whether the endoplasmic reticulum (ER) stress response could be a cyclooxygenase-2 (COX2)-independent mechanism of growth inhibition by celecoxib in a head and neck squamous cell carcinoma (HNSCC) cell line. 24692703 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE We used quantitative real-time PCR to examine the effects of three selective Cox-2 inhibitors, i.e., celecoxib, NS-398, and SC-791 on the gene expressions of E-cadherin (CDH-1) and its transcriptional repressors (SIP1, Snail, Twist) in the human HNSCC cell lines HSC-2 and HSC-4. 24887090 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE We found that not only COX-2 expression, but also the expression of 5-LO and CYP2J2 is up-regulated in head and neck squamous cell carcinoma (HNSCC) cell lines. 21656078 2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Our study suggests that, as COX-1 and COX-2 express and affect VEGF synthesis in HNSCC cells, we should check COX-1 expression in investigations on cancer treatment by inhibiting COX-2-induced prostaglandins. 21301321 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Importantly, treatment of HNSCC cells with GS abrogated both ST- and nicotine-induced nuclear activation of NF-κB and pSTAT3 proteins and their downstream targets COX-2 and vascular endothelial growth factor. 21177768 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Based on these results, the COX-2 haplotype ht3 can be used as a molecular biomarker to predict low risk groups of SCCHN in a Korean sample. 20592893 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE The results presented here show that HNSCC tumoral lesions and their derived cell lines constitutively express COX-2 and the EP1, EP2 and EP3 receptors for PGE2. 20951077 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE There was overexpression of COX-2 and its downstream enzyme mPGES-1, and their localization in tumor cells was similar, suggesting that these enzymes play both an important role in the development and proliferation of HNSCC. 20034753 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE The majority of the anticancer effects of COX-2-inhibitors in HNSCC cells seem to result from COX-2-independent action, suggesting that COX-1 and COX-2 may contribute to VEGF synthesis in cancer cells through a prostaglandin-dependent mechanism. 20222044 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Herein, we investigated whether the regulation of mitogen-activated protein kinases activity might be one of the main mechanisms related to a conspicuous COX-2-independent tumor-killing effect of celecoxib in HNSCC cell lines. 20717005 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Taken together, Sal-B shows promise as a COX-2 targeted anticancer agent for HNSCC prevention and treatment. 19123475 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE As Cox-2 is known to inhibit radiotherapy responses in SCCHN patients, data indicate an additional mechanism through which DeltaNp63 acts to promote cell survival and influence therapeutic response of SCCHN. 19391123 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE An inverse relationship between COX-2 and E-cadherin was shown in situ by double immunohistochemical staining of human HNSCC tissue sections. 19789323 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Bradykinin induced a concentration- and time-dependent induction of COX-2 protein in HNSCC, which was preceded by phosphorylation of EGFR and MAPK. 19074839 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma. 17875728 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE We did quantitative PCR analysis of cytochrome c oxidase (Cox) I and Cox II genes to measure changes in mtDNA content in pretreatment and posttreatment salivary rinses obtained from 76 patients undergoing surgical resection for primary head and neck squamous cell carcinoma. 16533782 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Tumours and clinically normal non-neoplastic tissue from SCCHN patients showed increased expression of COX-2 and PP2A. 16273222 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Our previous study revealed that simultaneously targeting epidermal growth factor receptor (EGFR) tyrosine kinase and cyclooxygenase-2 (COX-2) additively or synergistically inhibited growth of squamous cell carcinoma of the head and neck (SCCHN) in vitro. 16144930 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE We did quantitative PCR of cytochrome c oxidase I (Cox I) and cytochrome c oxidase II (Cox II) genes on oral rinse samples obtained from 94 patients with primary head and neck squamous cell carcinoma (HNSC) and a control group of 656 subjects. 15814624 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Overexpression of p53 markedly downregulated the transcription of COX-2, but the overexpression of p27 did not affect COX-2 levels in HNSCC cell lines. 15287038 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease CTD_human Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma--evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. 12969226 2003