Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.360 GeneticVariation disease BEFREE 307 non-coding transcripts differentially expressed in HNSCC were significantly correlated with patient survival, and associated with mutations in TP53, CDKN2A, CASP8, PRDM9, and FBXW7 and copy number variations in chromosomes 3, 5, 7, and 18. 27323410 2016
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.360 GeneticVariation disease BEFREE Although CASP8 mutations associated with cancer have been thought to promote tumorigenesis as a result of attenuation of the proapoptotic function of the protein, our results now show that most such mutations, including the novel G325A identified here, separately confer a gain of function with regard to activation of NF-κB signaling, indicating another role of CASP8 in the transformation of human malignancies including HNSCC. 23659359 2013
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.360 Biomarker disease CTD_human Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics. 23358896 2013
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.360 Biomarker disease BEFREE We recently reported that the reconstitution of procaspase-8 is sufficient for sensitizing cisplatin- but not etoposide-induced apoptosis, in chemoresistant and caspase-8 deficient HOC313 head and neck squamous cell carcinoma (HNSCC) cells. 21801448 2011
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.360 GeneticVariation disease BEFREE We concluded that the CASP8 -652 6N del variant allele may contribute to the risk of developing SCCHN in non-Hispanic white populations. 20086182 2010
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.360 AlteredExpression disease BEFREE The present study analyzes the expression of DR5 and caspase-8 by immunohistochemistry (IHC) in primary and metastatic HNSCCs and their impact on patient survival. 20808443 2010
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.360 GeneticVariation disease BEFREE However, the relationship between caspase-8 mutation and chemosensitivity remain unclear in head and neck squamous cell carcinoma (HNSCC) carrying p53 mutation. 19852930 2009