Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 268
Gene Symbol: AMH
AMH
0.010 AlteredExpression disease BEFREE When applied across 2-levels, MIS-TLIF using expandable lordotic interbody devices produced a significant increase in lumbar lordosis. 31584070 2020
Entrez Id: 2495
Gene Symbol: FTH1
FTH1
0.010 GeneticVariation disease BEFREE The MEDLINE via PubMed, Cochrane, Scopus, and Embase databases were searched for studies published between January 2010 and January 2019 evaluating outcomes including lumbar lordosis (LL), segmental lordosis (SL), slip rate, disc height (DH), back visual analogue scale (VAS), leg VAS, and Oswestry disability index (ODI) of ALIF with PPF or XLIF with PPF and TLIF or PLIF for spondylolisthesis. 31129223 2019
Entrez Id: 7908
Gene Symbol: EOS
EOS
0.010 Biomarker disease BEFREE EOS X-ray images were analyzed to determine spinal [lumbar lordosis (LL) and thoracic kyphosis (TK)] and pelvic parameters [pelvic obliquity (PO) and pelvic axial rotation (PR)]. 31332571 2019
Entrez Id: 3929
Gene Symbol: LBP
LBP
0.010 Biomarker disease BEFREE Our results suggest that LBPH is associated with increased stiffness of the lumbar multifidus muscle in the prone position, and that LBP is associated with the decreased lumbar lordosis in the standing position in community-dwelling middle-aged and elderly women. 30839423 2019
Entrez Id: 260402
Gene Symbol: IS1
IS1
0.010 Biomarker disease BEFREE Thoracic hypokyphosis following AIS correction may be associated with reduced lumbar lordosis with potential adverse effects on the global sagittal balance. 31388737 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.010 Biomarker disease BEFREE Thoracic hypokyphosis following AIS correction may be associated with reduced lumbar lordosis with potential adverse effects on the global sagittal balance. 31388737 2019
Entrez Id: 367
Gene Symbol: AR
AR
0.010 Biomarker disease BEFREE Thoracic hypokyphosis following AIS correction may be associated with reduced lumbar lordosis with potential adverse effects on the global sagittal balance. 31388737 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.010 Biomarker disease BEFREE RESULTS Interobserver reliability was excellent for preoperative PI and intraoperative LPA, T9PA, and T4PA (ICC = 0.88, 0.84, 0.84, and 0.93, respectively), good for intraoperative TPA (ICC = 0.68), and fair for preoperative SBFD (ICC = 0.60) and intraoperative LL (ICC = 0.50). 29775162 2018
Entrez Id: 3490
Gene Symbol: IGFBP7
IGFBP7
0.010 Biomarker disease BEFREE A larger LL was obtained with a higher incidence of proximal junctional kyphosis at long-term follow-up after PSF. 30030189 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.010 AlteredExpression disease BEFREE TNF-α and IL-6 mRNA expressions in paraspinal muscles were significantly higher in the decreased LL group than in the normal LL group (<i>P</i>=0.048 for both). 30233161 2018
Entrez Id: 923
Gene Symbol: CD6
CD6
0.010 Biomarker disease BEFREE The results of PI, PT, SS, LL, TK, CL, SVA, PR-T12, SSA and SPA values suggested that age was positively correlated with TK, CL and SVA, while it was negatively correlated with LL, PR-T12 and SSA. 30344686 2018
Entrez Id: 6421
Gene Symbol: SFPQ
SFPQ
0.010 Biomarker disease BEFREE A larger LL was obtained with a higher incidence of proximal junctional kyphosis at long-term follow-up after PSF. 30030189 2018
Entrez Id: 5067
Gene Symbol: CNTN3
CNTN3
0.010 AlteredExpression disease BEFREE XPA showed strong correlation to sagittal spinopelvic parameters-PT, SVA, lumbar lordosis (LL), pelvic incidence (PI) minus LL-and to HRQoL scores-ODI, SF-36 PCS and SRS-22 activity and pain. 29330576 2018
Entrez Id: 51107
Gene Symbol: APH1A
APH1A
0.010 Biomarker disease BEFREE A larger LL was obtained with a higher incidence of proximal junctional kyphosis at long-term follow-up after PSF. 30030189 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.010 AlteredExpression disease BEFREE TNF-α and IL-6 mRNA expressions in paraspinal muscles were significantly higher in the decreased LL group than in the normal LL group (<i>P</i>=0.048 for both). 30233161 2018
Entrez Id: 952
Gene Symbol: CD38
CD38
0.010 Biomarker disease BEFREE Observe the prevalence, type and distribution characteristics of Modic changes occurred at the vertebral endplate from T10 to S1;analyse the correlation between Modic changes and disc degeneration, the sagittal vertical axis (SVA), thoracic kyphosis (TK), thoracolumbar kyphosis (TLK), lumbar lordosis (LL), sacral slope (SS), pelvic tilt (PT) and pelvic incidence (PI). 29763470 2018
Entrez Id: 4184
Gene Symbol: SMCP
SMCP
0.010 GeneticVariation disease BEFREE Preoperatively to 12-month follow-up there were increases in segmental lordosis (7.9-9.4 degrees, P=0.0497), lumbar lordosis (48.8-55.2 degrees, P=0.0328), and disk height (3.7-5.5 mm, P=0.0018); there were also improvements in back (58.6%) and leg pain (60.0%), ODI (44.4%), PCS (56.7%), and MCS (16.1%) for stand-alone XLIF. 28207620 2017
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.010 Biomarker disease BEFREE PI; pelvic incidence; SS; sacral slope; PT; pelvic tilt; LL; lumbar lordosis; C7SVA; C7 sagittal vertical axis; SSA; spinosacral angle; TK; thoracic kyphosis; C2-C7SVA; C2-C7 sagittal vertical axis; C2-C7A; C2-C7 Angle; TIA; thoracic inlet angle; NT; neck tilt. 28248611 2017
Entrez Id: 55034
Gene Symbol: MOCOS
MOCOS
0.010 GeneticVariation disease BEFREE Preoperatively to 12-month follow-up there were increases in segmental lordosis (7.9-9.4 degrees, P=0.0497), lumbar lordosis (48.8-55.2 degrees, P=0.0328), and disk height (3.7-5.5 mm, P=0.0018); there were also improvements in back (58.6%) and leg pain (60.0%), ODI (44.4%), PCS (56.7%), and MCS (16.1%) for stand-alone XLIF. 28207620 2017
Entrez Id: 55906
Gene Symbol: ZC4H2
ZC4H2
0.010 GeneticVariation disease BEFREE Preoperatively to 12-month follow-up there were increases in segmental lordosis (7.9-9.4 degrees, P=0.0497), lumbar lordosis (48.8-55.2 degrees, P=0.0328), and disk height (3.7-5.5 mm, P=0.0018); there were also improvements in back (58.6%) and leg pain (60.0%), ODI (44.4%), PCS (56.7%), and MCS (16.1%) for stand-alone XLIF. 28207620 2017
Entrez Id: 221527
Gene Symbol: ZBTB12
ZBTB12
0.010 GeneticVariation disease BEFREE But LL (42.0°) in the TLD was significantly higher than in the NG (35°). 28383441 2017
Entrez Id: 811
Gene Symbol: CALR
CALR
0.010 Biomarker disease BEFREE PI; pelvic incidence; SS; sacral slope; PT; pelvic tilt; LL; lumbar lordosis; C7SVA; C7 sagittal vertical axis; SSA; spinosacral angle; TK; thoracic kyphosis; C2-C7SVA; C2-C7 sagittal vertical axis; C2-C7A; C2-C7 Angle; TIA; thoracic inlet angle; NT; neck tilt. 28248611 2017
Entrez Id: 414
Gene Symbol: ARSD
ARSD
0.020 Biomarker disease BEFREE As demonstrated in ASD, one of the causes of PJK might be postoperative posterior imbalance that can be due to increased LL, insufficient TK or inflection point shift during surgery. 29959554 2018
Entrez Id: 414
Gene Symbol: ARSD
ARSD
0.020 Biomarker disease BEFREE However, PI-LL mismatching didn't affect HRQoL scores at the last follow-up, which was different from the results of previous studies in the settings of ASD. 29631110 2018
Entrez Id: 140821
Gene Symbol: RSS
RSS
0.030 GeneticVariation disease BEFREE There were no relationships between coronal deformity, thoracic kyphosis, or lumbar lordosis with SRS-22r scores. 31674249 2019