Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE MDM2 is known to be altered in various human sarcomas. 31732813 2019
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE Global overexpression through increased Mdm2 gene copy number (Mdm2<sup>Tg</sup> ) results in the development of hematopoietic neoplasms and sarcomas in adult animals. 30011084 2018
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 AlteredExpression group BEFREE To differentiate DDLPS, we investigated MDM2 amplification and expression in high-grade spindle sarcomas. 27028243 2018
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE We compared sensitivity and specificity of p16 IHC to MDM2 and CDK4 IHC in the differential diagnosis of ALT-WDLPS (n=19) versus benign adipocytic tumors (n=44) and DDLPS (n=18) versus mimicking sarcomas (n=20). 27597521 2017
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE Many malignancies display amplification of MDM genes encoding negative regulators of p53 and therefore much effort to date has concentrated on the development of molecules that inhibit MDM2, the most advanced of which are being tested in clinical trials for sarcoma, glioblastoma, bladder cancer and lung adenocarcinoma. 28927521 2017
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 GeneticVariation group BEFREE Four years later in a second examination with molecular methods for a study of adrenal sarcomas, this diagnosis must be revised due to the lack of MDM-2 gene amplification and FKHR translocation which exclude sarcoma. 27688079 2017
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE This article provides an overview of these events in human cancer, highlighting the frequent occurrence of MDM2 amplification in sarcoma and the role of SNP309 and SNP285 in regulating MDM2 expression and cancer risk. 27194168 2016
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE Nutlin inhibits TP53-MDM2 interaction and is under investigation in soft-tissue sarcomas (STS) and other malignancies. 26427052 2015
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE Inhibition of MDM2 by RG7388 confers hypersensitivity to X-radiation in xenograft models of childhood sarcoma. 25832557 2015
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 GeneticVariation group BEFREE This meta-analysis provides evidence that MDM2 SNP rs2279744 may be significantly associated with increased risk of sarcoma in Caucasian individuals. 25366142 2015
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE MDM2/4 antagonists, on the other hand, are likely to be efficacious in malignancies in which MDM2 or MDM4 is overexpressed such as sarcomas, neuroblastomas and specific childhood leukemias. 25455730 2014
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 GeneticVariation group BEFREE In line with this, sarcomas with MDM2-negative rings commonly show complete loss of either CDKN2A or RB1 -both known to be important for genome integrity. 24070870 2014
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE Collectively, our findings argue that the existing benchmark biomarker for MDM2 antagonist efficacy (MDM2 amplification) should not be used to predict outcome but rather global gene expression profiles and epigenetic status of sarcomas dictate their sensitivity to p53/MDM2 antagonists. 24336067 2014
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 GeneticVariation group BEFREE Our meta-analysis indicates that the HDMX polymorphism is unlikely to contribute to individual susceptibility to sarcoma. 24972690 2014
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE We compared the clinical data, histologic data, MDM2 status (immunohistochemistry [IHC], fluorescence in situ hybridization [FISH]), genomic profile (array comparative genomic hybridization), and follow-up of 19 patients with peripheral UPS with MDM2 amplification and 62 with peripheral conventional DDLPS retrieved from the French sarcoma network (RRePS) and the Conticabase (Connective Tissue Cancer Network database). 24525499 2014
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 GeneticVariation group BEFREE Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma. 23165797 2013
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 AlteredExpression group BEFREE We used fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) to detect MDM2 amplification and protein overexpression, respectively, in 49 WDLSs, 5 DDLSs, 23 myxoid liposarcomas, 25 benign lipomatous tumors, and 75 spindle and pleomorphic sarcomas. 23826411 2013
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 GeneticVariation group BEFREE For MDM2 T309G variant, pooled results from the meta-analysis indicate that carriers of TG and GG genotypes showed a 34% increased risk to develop sarcomas compared to TT carriers. 22205265 2012
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE Chromosomal enrichment analysis of genes showed a highly significant impact at cytoband 7q22 (chromosome 7) which included mouse double minute (MDM2) and cyclin-dependant kinase (CDK4) as well as other genes associated with human sarcomas. 22982072 2012
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 GeneticVariation group BEFREE A constitutional G allele has also been associated with earlier onset of various cancer types, and studies of sarcomas have shown an enrichment of the G allele in tumors with MDM2 amplification, notably atypical lipomatous tumor (also known as well-differentiated liposarcoma). 22939400 2012
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 GeneticVariation group BEFREE The human homolog of the mouse double minute 2 (MDM2) oncogene is amplified in about 20% of sarcomas. 20881839 2011
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE Although MDM2 is almost always positive in well-differentiated liposarcoma, which is useful in differentiating benign from atypical/well-differentiated lipomatous tumor, it should not be used in differentiating liposarcoma from other sarcomas. 21666577 2011
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 Biomarker group BEFREE We propose, therefore, that MDM2 markers along with TP53 sequencing should be considered as patient biomarkers in clinical trials of sarcomas using MDM2 antagonists. 21159888 2011
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 AlteredExpression group BEFREE MDM2 is consistently amplified in well-differentiated liposarcomas/atypical lipomatous tumors, and up to 25% in other sarcomas. 19820690 2009
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.400 AlteredExpression group BEFREE A change in the expression levels of the HDM2 transcripts originating from the two HDM2 promoters could disrupt the oscillating P53-HDM2 feedback loop in a way that elevated levels of HDM2-P1 transcript are associated with an earlier age of tumor onset and that reduced levels of HDM2-P1 or HDM2-P2 transcripts are correlated with poor prognosis of patients with soft tissue sarcomas. 18922973 2008