Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 Biomarker group BEFREE In contrast, localized administration of TNF-alpha in the form of isolated limb perfusion have yielded excellent results in soft tissue sarcomas. 30170620 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 Biomarker group BEFREE Lipid Nanoparticles Decorated with TNF-Related Aptosis-Inducing Ligand (TRAIL) Are More Cytotoxic than Soluble Recombinant TRAIL in Sarcoma. 29757258 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 Biomarker group BEFREE BCAP-1 markedly inhibited Sarcoma 180tumor growth in tumor-bearing mice, and increased the secretion of TNF-α in serum. 27884671 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 AlteredExpression group BEFREE Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells. 19577358 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 Biomarker group BEFREE Recombinant tumor necrosis factor-alpha (TNF-alpha) combined to melphalan is clinically administered through isolated limb perfusion (ILP) for regionally advanced soft tissue sarcomas of the limbs. 18065405 2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 Therapeutic group CTD_human A combination of doxorubicin and tumor necrosis factor alpha (TNFalpha) has been proven to be very effective in the perfusional treatment of advanced soft tissue limb sarcoma both in terms of tumor necrosis and limb conservative surgery rate. 17203757 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 Therapeutic group CTD_human Hyperthermic isolated perfusion with low-dose TNFalpha and doxorubicin in patients with locally advanced soft tissue limb sarcomas. 15675481 2004
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 Biomarker group BEFREE In addition, isolated limb perfusion is a unique approach to delivery of drugs, such as TNF and melphalan, for sarcomas and melanomas [137, 138]. 12916466 2003
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 Biomarker group BEFREE Five human soft tissue sarcoma (STS) cell lines (HTB-82 rhabdomyosarcoma, HTB-91 fibrosarcoma, HTB-92 liposarcoma, HTB-93 synovial sarcoma and HTB-94 chondrosarcoma) were analysed for their sensitivity to tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and the function of the TRAIL apoptotic pathway in these cells. 12763223 2003
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 Therapeutic group CTD_human Many antineoplastic drugs have been associated to hyperthermia by isolation limb perfusion, the aim of this paper was to describe the results obtained with doxorubicin in association to hyperthermia with or without Tumor Necrosis Factor (TNF) alpha in order to identify the most effective regimen in the multidisciplinary treatment of soft tissue limb sarcoma. 16767912 2003
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 Biomarker group BEFREE Isolated, hyperthermic limb perfusion (ILP) with recombinant human tumor necrosis factor alpha and melphalan is a highly effective treatment for advanced soft tissue sarcoma (STS) and locoregional metastatic malignant melanoma. 12149303 2002
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.380 Therapeutic group CTD_human Clinical applications of TNF-alpha in cancer. 9794839 1998