Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 761
Gene Symbol: CA3
CA3
0.500 Biomarker disease CTD_human Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. 25231249 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.500 Biomarker disease CTD_mouse Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice. 26134275 2015
Entrez Id: 761
Gene Symbol: CA3
CA3
0.500 Biomarker disease CTD_mouse Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.500 Biomarker disease CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750 2011
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.340 Biomarker disease CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043 2018
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.340 Biomarker disease BEFREE No tagging single-nucleotide polymorphisms (tSNPs) of cytochrome P450 2E1(CYP2E1) in the risk of anti-TB drug-induced hepatitis have been reported. 23460870 2013
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.340 Biomarker disease CTD_human Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices. 21741958 2011
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.340 GeneticVariation disease BEFREE NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. 20392357 2010
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.340 GeneticVariation disease BEFREE Moreover, a significant association of CYP2E1 in the Chinese, NAT2 in Koreans and glutathione S-transferase genotypes in Caucasians has been reported with antituberculus drug-induced hepatitis. 20485159 2010
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.340 Biomarker disease CTD_human CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis. 16770646 2006
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.340 Biomarker disease CTD_human The aim of this study was to evaluate whether the polymorphism of the CYP2E1 gene is associated with antituberculosis drug-induced hepatitis. 12668988 2003
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.340 GeneticVariation disease BEFREE The aim of this study was to evaluate whether the polymorphism of the CYP2E1 gene is associated with antituberculosis drug-induced hepatitis. 12668988 2003
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.330 Biomarker disease CTD_human Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity. 25693865 2015
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.330 GeneticVariation disease BEFREE NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. 20392357 2010
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.330 Biomarker disease BEFREE Most prior genetic studies on antituberculus drug-induced hepatitis have focused on a few drug-metabolizing enzymes such as cytochrome P450 and N-acetyltransferase 2. 20485159 2010
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.330 Biomarker disease CTD_human Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis. 17950035 2007
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.330 Biomarker disease CTD_human Verified predominance of slow acetylator phenotype N-acetyltransferase 2 (NAT2) in a Hmong population residing in Minnesota. 16799928 2006
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.330 Biomarker disease CTD_human To determine whether acetylator status is a risk factor for antituberculosis drug-induced hepatitis, we genotyped NAT2 in 224 incident tuberculosis patients who received antituberculosis treatment. 11915035 2002
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.330 Biomarker disease BEFREE In conclusion, slow-acetylator status of NAT2 is a significant susceptibility risk factor for antituberculosis drug-induced hepatitis. 11915035 2002
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.310 Therapeutic disease CTD_human Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. 30215777 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.310 Biomarker disease BEFREE We previously demonstrated that lansoprazole provided hepatoprotection in a drug-induced hepatitis animal model partially through the Nrf2/HO-1 pathway. 29355950 2018
Entrez Id: 1555
Gene Symbol: CYP2B6
CYP2B6
0.310 Biomarker disease CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.310 Therapeutic disease CTD_human P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2. 26958860 2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.310 Therapeutic disease CTD_human Nrf2 protects against furosemide-induced hepatotoxicity. 24813929 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.310 Biomarker disease CTD_human Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. 21984482 2012