×
Entrez Id:
761
Gene Symbol:
CA3
CA3
0.500
Biomarker
disease
CTD_human
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
25231249
2015
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
0.500
Biomarker
disease
CTD_mouse
Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice.
26134275
2015
×
Entrez Id:
761
Gene Symbol:
CA3
CA3
0.500
Biomarker
disease
CTD_mouse
Characterization of chemically induced liver injuries using gene co-expression modules.
25226513
2014
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
0.500
Biomarker
disease
CTD_human
Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood.
20623750
2011
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
0.340
Biomarker
disease
CTD_human
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.
28762043
2018
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
0.340
Biomarker
disease
BEFREE
No tagging single-nucleotide polymorphisms (tSNPs) of cytochrome P450 2E1 (CYP2E1 ) in the risk of anti-TB drug-induced hepatitis have been reported.
23460870
2013
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
0.340
Biomarker
disease
CTD_human
Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices.
21741958
2011
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
0.340
GeneticVariation
disease
BEFREE
NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis .
20392357
2010
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
0.340
GeneticVariation
disease
BEFREE
Moreover, a significant association of CYP2E1 in the Chinese, NAT2 in Koreans and glutathione S-transferase genotypes in Caucasians has been reported with antituberculus drug-induced hepatitis .
20485159
2010
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
0.340
Biomarker
disease
CTD_human
CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis.
16770646
2006
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
0.340
Biomarker
disease
CTD_human
The aim of this study was to evaluate whether the polymorphism of the CYP2E1 gene is associated with antituberculosis drug-induced hepatitis .
12668988
2003
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
0.340
GeneticVariation
disease
BEFREE
The aim of this study was to evaluate whether the polymorphism of the CYP2E1 gene is associated with antituberculosis drug-induced hepatitis .
12668988
2003
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
0.330
Biomarker
disease
CTD_human
Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity.
25693865
2015
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
0.330
GeneticVariation
disease
BEFREE
NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis .
20392357
2010
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
0.330
Biomarker
disease
BEFREE
Most prior genetic studies on antituberculus drug-induced hepatitis have focused on a few drug-metabolizing enzymes such as cytochrome P450 and N-acetyltransferase 2 .
20485159
2010
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
0.330
Biomarker
disease
CTD_human
Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis.
17950035
2007
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
0.330
Biomarker
disease
CTD_human
Verified predominance of slow acetylator phenotype N-acetyltransferase 2 (NAT2) in a Hmong population residing in Minnesota.
16799928
2006
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
0.330
Biomarker
disease
CTD_human
To determine whether acetylator status is a risk factor for antituberculosis drug-induced hepatitis , we genotyped NAT2 in 224 incident tuberculosis patients who received antituberculosis treatment.
11915035
2002
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
0.330
Biomarker
disease
BEFREE
In conclusion, slow-acetylator status of NAT2 is a significant susceptibility risk factor for antituberculosis drug-induced hepatitis .
11915035
2002
×
Entrez Id:
4780
Gene Symbol:
NFE2L2
NFE2L2
0.310
Therapeutic
disease
CTD_human
Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor.
30215777
2019
×
Entrez Id:
4780
Gene Symbol:
NFE2L2
NFE2L2
0.310
Biomarker
disease
BEFREE
We previously demonstrated that lansoprazole provided hepatoprotection in a drug-induced hepatitis animal model partially through the Nrf2 /HO-1 pathway.
29355950
2018
×
Entrez Id:
1555
Gene Symbol:
CYP2B6
CYP2B6
0.310
Biomarker
disease
CTD_human
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.
28762043
2018
×
Entrez Id:
4780
Gene Symbol:
NFE2L2
NFE2L2
0.310
Therapeutic
disease
CTD_human
P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2.
26958860
2016
×
Entrez Id:
4780
Gene Symbol:
NFE2L2
NFE2L2
0.310
Therapeutic
disease
CTD_human
Nrf2 protects against furosemide-induced hepatotoxicity.
24813929
2014
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.310
Biomarker
disease
CTD_human
Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha.
21984482
2012