Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation. 30849401 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE The DAT is the molecular target for cocaine and amphetamine as well as a number of pathological conditions including autism spectrum disorders, attention-deficit hyperactivity disorder (ADHD), dopamine transporter deficiency syndrome (DTDS), and Parkinson's disease. 30828290 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 AlteredExpression disease BEFREE Altered expression of DAT is linked to neurodevelopmental disorders, including attention deficit hyperactivity disorder and autism spectrum disorder, and is shown to contribute to the response of psychotropic drugs and neurotoxicants. 31749842 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Several lines of evidence indicate that DAT dysfunction is linked to neuropsychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BPD), and autism spectrum disorder (ASD). 30153408 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE Several meta-analyses showed small but significant association between the 10-repeat allele in the DAT1 gene in 3'-untranslated region variant number tandem repeat polymorphism and child and adolescent ADHD, whereas in adult ADHD the 9-repeat allele was suggested to confer as risk allele. 30923918 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE Dopamine transporter genotype modulates brain activity during a working memory task in children with ADHD. 31306870 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE The dopamine transporter (DAT) has received continuous attention as a potential risk factor for psychiatric disease, as it is critical for dopamine homeostasis and serves as principal target for ADHD medications. 29559554 2018
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 PosttranslationalModification disease BEFREE Overall, these findings suggest that peripheral DAT1 promoter methylation may be predictive of striatal DAT availability in adults with ADHD. 30033547 2018
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE COMT and DAT1 polymorphisms moderate the indirect effect of parenting behavior on youth ADHD symptoms through neurocognitive functioning. 28675949 2018
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 AlteredExpression disease BEFREE This work presents a different means (i.e. other than direct blockade by a DAT inhibitor) to regulate the activity of DAT and dopaminergic neurotransmission, and a potential target site for future development of ADHD treatments. 30413217 2018
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Adults with ADHD had both abnormal DAT availability and P300 amplitude, suggesting that ADHD is linked to dysfunction of the central dopaminergic system and poor cognitive processes related to response selection and execution. 28847342 2018
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Adolescents with ADHD who showed a robust response to OROS-MPH (n = 7) had significantly greater reduction of DAT density in the right putamen than adolescents who showed less robust response to OROS-MPH (n = 13) (p = 0.02). 29684537 2018
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 PosttranslationalModification disease BEFREE DAT methylation levels were greatly reduced in ADHD patients compared to control, healthy children. 28822049 2018
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE Our findings suggest that the DAT1-related GMV alterations in the posterior cortical regions may contribute to visual memory performance in children with ADHD. 29433615 2018
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE This meta-analysis investigated the potential role of SLC6A3 polymorphisms in response to MPH in children with ADHD. 29171685 2018
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Dopamine transporter (DAT) knockout (KO) and heterozygous (HET) mice, in particular, have been widely used to study ADHD. 29520239 2018
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE Our findings provide initial evidence for the involvement of the epigenetic alterations of DAT1 in modulating the response to MPH treatment in ADHD, primarily on oppositional and hyperactive-impulsive symptoms. 27676100 2017
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE This study supports the idea that being born SGA moderates the effect of the DAT1 gene on ADHD symptoms in the preschool years and may help to explain some of the heterogeneity in ADHD outcomes. 28666839 2017
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 AlteredExpression disease BEFREE Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous Hypertensive Rats. 28293263 2017
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE The unique and interactive contributions of a maternal dopamine receptor gene (DAT1), maternal ADHD symptoms (hyperactive- impulsive, inattentive), and home atmosphere to the prediction of ADHD symptoms (hyperactive- impulsive, inattentive) in 7- year-old boys (N = 96) were examined using data from a longitudinal study of familial risk for ADHD. 27873141 2017
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Amphetamine and methylphenidate are known to have stimulatory effect in healthy subjects but not in humans with attention deficit hyperactivity disorder and in rodents with impaired dopamine transporter (DAT) function. 28750831 2017
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Dopamine transporter gene (DAT1) has been implicated in attention deficits. 28757070 2017
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE DAT is the target for psychostimulants-like cocaine and amphetamine-and plays an important role in neuropsychiatric disorders, including attention-deficit hyperactivity disorder and drug addiction. 28894302 2017
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE Given that prenatal exposure to alcohol or smoking is known to affect dopamine-rich brain regions, we hypothesized that individuals carrying the ADHD risk alleles of the dopamine receptor D4 (<i>DRD4</i>) and dopamine transporter (<i>DAT1</i>) genes may be especially sensitive to their effects. 28234207 2017
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE Many neurological disorders such as schizophrenia, bipolar disorder, Parkinson disease and attention-deficit hyperactivity disorder are associated with imbalances in DA homeostasis that may be related to DAT dysfunction. 28115272 2017