Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.080 | Biomarker | disease | BEFREE | Here, we asked whether ATRX deficiency creates a vulnerability in ALT cancer cells that could be exploited for therapeutic purposes. | 30745338 | 2019 | ||||
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0.080 | GeneticVariation | disease | BEFREE | ATRX alterations are strongly associated with the presence of the alternative lengthening of telomeres (ALT) phenotype, and within the central nervous system they tend to occur in subsets of gliomas, including those with IDH, NF1, or histone (H3 K27M or G34) mutations. | 31225581 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | RAP1 or XRCC1 downregulation cooperated with ATRX loss in driving the ALT phenotype. | 29545335 | 2018 | ||||
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0.080 | Biomarker | disease | BEFREE | ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner. | 30226859 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | In astrocytic tumors, loss of immunoreactivity for the ATRX protein was significantly associated to the ALT phenotype (p = 0.0003). | 27796734 | 2017 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | These include the alternative lengthening of telomeres (ALT) phenotype associated with mutations in the ATRX and DAXX genes and recurrent point mutations in the TERT gene promoter. | 28040793 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Forced resolution of sister telomere cohesion induces excessive recombination between non-homologs, genomic instability, and impaired cell growth, indicating the ATRX-macroH2A1.1-tankyrase axis as a potential therapeutic target in ALT tumors. | 26373281 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Of the other alterations examined, only ATRX point mutations and reduced expression were associated with the ALT phenotype (p = 0.0005). | 25315281 | 2014 |