Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.070 | PosttranslationalModification | disease | BEFREE | BDNF exon IV and p11 promoter methylation was not associated with test performance.<b>Conclusions:</b> Our results corroborate a concomitant amelioration of executive dysfunctions with successful antidepressant therapy and support a role of BDNF in the neural mechanisms underlying the normalisation of executive dysfunctions in MDD.<b>ClinicalTrials.gov number:</b> NCT00974155; EudraCT: 2008-008280-96. | 29334322 | 2019 | ||||
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0.070 | PosttranslationalModification | disease | BEFREE | Next, we investigated the predictive properties of p11 promoter methylation in two clinical cohorts of patients with pharmacoresistant MDD. | 29353887 | 2018 | ||||
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0.070 | Biomarker | disease | BEFREE | Furthermore, p11 has been implicated in major depressive disorder (MDD) and in the actions of antidepressants. | 27616678 | 2017 | ||||
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0.070 | AlteredExpression | disease | BEFREE | We measured levels of p11 and P2RX7 mRNA in peripheral blood mononuclear cells (PBMCs) of 26 psychiatric patients (11 suicide attempters, 15 suicide non-attempters) with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), and 14 normal controls, using quantitative real-time PCR. | 20863517 | 2011 | ||||
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0.070 | AlteredExpression | disease | BEFREE | We found that patients with PTSD had lower levels of p11 mRNA than control subjects, while those with MDD, BP and SCZ had significantly higher p11 levels than the controls. | 19380152 | 2009 | ||||
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0.070 | GeneticVariation | disease | BEFREE | The analysis for genotypic effects showed no significant association between any of the three p11 single nucleotide polymorphisms (SNPs) and MDD therapeutic response. | 18838110 | 2008 | ||||
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0.070 | Biomarker | disease | BEFREE | Our results do not support a major role for either common or rare p11 SNPs with MDD. | 17510952 | 2007 |