Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease BEFREE Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression. 29317606 2018
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 AlteredExpression disease BEFREE The plasma CRH levels were significantly higher in MDD patients than in controls. 28755509 2018
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease BEFREE Gene-wide significant results were found for dexamethasone suppression (CYP11A1, CYP17A1, POU1F1, AKR1D1), hippocampal volume (CYP17A1, CYP11A1, HSD3B2, PROP1, AVPRA1, SRD5A1), amygdala volume (POMC, CRH, HSD3B2), and lifetime MDD diagnosis (FKBP5 and CRH), all permutation p-values<0.05. 28589964 2017
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease BEFREE Forty-five parous (12-24 months postpartum), euthymic women with history of MDD (n = 15), PPD (n = 15), and controls (n = 15) completed pharmacologic (dexamethasone/corticotropin-releasing hormone (CRH) test [DEX/CRH]) and psychological (Trier social stress test [TSST]) challenges during the luteal phase. 28251369 2017
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease BEFREE This review presents the current state of knowledge on CRF physiology, and how it may influence the occurrence of symptoms associated with MDD. 26271720 2015
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease BEFREE Although these preliminary observations require further confirmation in future studies, these results on the interaction between CRH haplotypes and SLEs, suggest that CRH ht1 which is moderated by SLEs, may be associated with antidepressant treatment outcomes in patients with MDD. 26055202 2015
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease PSYGENET Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder. 23529111 2013
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease BEFREE The corticotropin-releasing hormone (CRH) system coordinates neuroendocrine and behavioral responses to stress and has been implicated in the development of major depressive disorder (MDD). 22378896 2012
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease PSYGENET The corticotropin-releasing hormone (CRH) system coordinates neuroendocrine and behavioral responses to stress and has been implicated in the development of major depressive disorder (MDD). 22378896 2012
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease PSYGENET In addition, persistent elevation of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) concentrations following early-life adversity has been posited to underlie the subsequent development of major depression. 20692103 2011
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 AlteredExpression disease BEFREE Within a larger sample of 541 inpatients with major depressive disorder (MDD), we then tested associations of one PPGAL tag SNP with specific depression symptom clusters and HPA-axis activity assessed by the combined dexamethasone-suppression/CRH-stimulation test both at inpatient admission and discharge (n=298). 20237460 2010
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 AlteredExpression disease BEFREE We found reduced mRNA expression of REST and increased mRNA expression of CRH, adenylate cyclase 5, and the tumor necrosis factor superfamily, member 12-13 in patients with major depressive disorder in a current depressive state, but not in a remissive state. 19846118 2010
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease PSYGENET Our results suggest that the aberrant REST-mediated transcriptional regulation of, at least, CRH, adenylate cyclase 5, and tumor necrosis factor superfamily, member 12-13, might be state-dependent and associated with the pathophysiology of major depression. 19846118 2010
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease PSYGENET Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. 20029939 2010
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 GeneticVariation disease BEFREE In this study, we tested whether the polymorphisms of three sites (rs1876828, rs242939 and rs242941) in corticotropin-releasing hormone receptor1 (CRHR1) gene are related to 6 weeks fluoxetine antidepressant effect in 127 Han Chinese patients with MDD. 17258395 2007
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 GeneticVariation disease BEFREE The subsequent gender analysis showed significant associations of three SNPs (CRF-BPs2 T; CRF-BPs11 T and CRF-BPs12 C) and haplotype G_T_C_T_C with MDD in Swedish males. 17599466 2007
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease BEFREE Many pieces of evidence supported that corticotropin-releasing hormone (CRH) play a role in the pathophysiology of major depression. 16815632 2006
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease BEFREE A function test combining the pre-treatment of 1.5 mg dexamethasone (DEX) with a challenge of 100 microg corticotropin-releasing hormone (CRH) reveals a pathological increase in the adrenocorticotropin and cortisol release in patients with major depression. 15504420 2005
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease BEFREE This review focuses on hyperdrive of corticotropin-releasing hormone (CRH) as the fundamental neurobiological correlate of MDD. 15196881 2004
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease BEFREE Recent research suggests that central corticotropin releasing hormone hyperdrive is an important neurobiological risk factor for developing major depression. 14573312 2003
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.400 Biomarker disease BEFREE This differential effect of glucocorticoid on CRH mRNA regulation could help explain the abnormal CRH production observed in clinical disorders such as anorexia nervosa and major depression. 1547737 1992