Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE While both MDD-DE and MDD-IN exhibited lower HEI scores than HC, only MDD-IN showed higher plasma interleukin-1 receptor antagonist (IL-1RA) and interleukin-6 (IL-6) levels than HC. 31818803 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 GeneticVariation disease BEFREE Moreover, logistic regression analyses correctly classified BD and MDD patients with 98.1% accuracy, using a combination of IL-6, IL-8, ST2, sTNFR2 (directly associated with BD) and IL-12 and TNF-α (directly associated with MDD). 31693974 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE The MDD group manifested an elevated HPAA activity as well as IL-6 and CNTF levels at baseline. 30564974 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Some researchers suggested that the elevation of interleukin-6 (IL6) correlates with major depression and PTSD. 31291232 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Pre-treatment leptin showed a significant clinical correlation with reduction of panic symptoms in MDD patients at visit 5 (p=0.011), whereas pre-treatment IL-6 showed a negative correlation with panic symptom reduction in PD patients (p=0.022). 31669792 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE While cross-sectional associations of inflammatory markers interleukin-6 (IL-6) and C-reactive protein with major depressive disorder are well established, evidence for longitudinal associations mostly comes from studies on depression symptoms, not diagnoses. 30819515 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE No correlations existed between plasma IL-6 levels and plasma catecholamine metabolite levels in patients with MDD, and the severity of depressive state was related to plasma IL-6 levels in MDD. 31686824 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE At baseline, the patients with MDD + AUD showed higher levels of inflammatory biomarkers IL-6 (p < 0.001), hs-CRP (p < 0.01), YKL-40 (p < 0.05), and biomarkers of alcohol consumption, than the corresponding group of non-AUD patients. 30769022 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 GeneticVariation disease BEFREE Sex difference in IL-6 modulation of cognition among Chinese individuals with major depressive disorder. 31629608 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE With the exception of TC and LDLs, our findings do not support the hypothesis that IL-6 and INF-γ levels and lipid profile are associated with suicide attempts in adult patients with MDD. 30844329 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE MDD and BD groups showed significantly higher serum IL-6 levels (p ≤ 0.001) and IL-10 levels (p ≤ 0.001) when compared to healthy control group. 31207853 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE We found significantly elevated concentrations of serum IL-6 in MDD patients compared with control subjects (p < 0.001). 30899619 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Correlational analyses were conducted between interleukin-6 (IL-6) and volume in a priori regions implicated in the pathophysiology of major depressive disorder (MDD). 31615590 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE CSF levels of IL-6 and TNF-α were higher in patients with MDD compared with controls (standardised mean difference SMD 0.37, 95%CI: 0.17-0.57 and SMD 0.58, 95%CI 0.26-0.90, respectively). 31195092 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Therefore, we assessed these variables in a group of patients with major depressive disorder (MDD) and measured levels of the pro-inflammatory cytokine IL-6 and the anti-inflammatory cytokine IL-10. 31063941 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Here, we assessed the differences in serum levels of interleukin 6 (IL-6) and interleukin 8 (IL-8) as well as C-reactive protein (CRP) in patients with MDD and BD. 30762747 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Our results show that patients with MDD without other comorbidities (N = 33) exhibited significantly higher levels of pro-inflammatory IL-12 and IL-6 in plasma and that these cytokines were associated with increased numbers of non-classical (CD11b<sup>+</sup>CD16<sup>bright</sup>CD14<sup>neg</sup>) monocytes and increased activation state (CD40<sup>+</sup>CD86<sup>+</sup>) of classical monocytes in circulation. 31753725 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE The level of IL-6 was associated with sleep disturbances in patients with major depressive disorder. 31417262 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Higher concentration of interleukin 6 - A possible link between major depressive disorder and childhood abuse. 29626828 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE A consistent body of research has confirmed that patients with major depressive disorder (MDD) have increased concentrations of pro-inflammatory cytokines, including IL-6, TNF-α, IL-1β, the soluble IL-2 receptor, and C-reactive protein, compared to controls; however, there is limited information on IL-17A in MDD. 29069253 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Eight eligible studies were found.Overall, serum interleukin-6 and 1β values were increased in the melancholic MDD subtype compared to controls and the non-melancholic MDD subtype. 29935756 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE MDD in elderly subjects is associated with decline in cognitive functions that may be related to peripheral IL-6 levels. 28338340 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 GeneticVariation disease BEFREE Compared with healthy controls, women with MDD in pregnancy had raised interleukin (IL) IL-6 (effect size (δ) = 0.53, p = 0.031), IL-10 (δ = 0.53, p = 0.043), tumor necrosis factor alpha (δ = 0.90, p = 0.003) and vascular endothelial growth factor (δ = 0.56, p = 0.008), together with raised diurnal cortisol secretion (δ = 0.89, p = 0.006), raised evening cortisol (δ = 0.64, p = 0.004), and blunted cortisol awakening response (δ = 0.70, p = 0.020), and an 8-day shorter length of gestation (δ = 0.70, p = 0.005). 30033161 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Plasma mtDNA concentration was measured with real-time quantitative PCR targeting two regions of the mtDNA and plasma levels of four cytokines (GM-CSF, IL-2, IL-4, and IL-6) were measured with a multiplex immunoassay method in 109 patients with major depressive disorder (MDD). 28633757 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Furthermore, MDD patients showed higher levels of IL-6 and a trend for higher CRP levels, which were also associated with similar alterations in the serum N-glycan profile as those characteristic for MDD patients. 29529546 2018