Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.600 | Biomarker | disease | PSYGENET | Our study included 2679 participants.Those with both the 5-HTTLPR s allele and the BDNF Met allele showed the highest risk of MD if they had previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 0.029) or any kind of childhood abuse (z = 2.37, p = 0.018). | 25510949 | 2015 | ||||
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0.600 | Biomarker | disease | PSYGENET | Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET182C) polymorphisms are associated with susceptibility and treatment response in major depressive disorder (MDD). | 25650523 | 2015 | ||||
|
0.600 | Biomarker | disease | PSYGENET | We therefore investigated whether variation in hippocampus, amygdala, orbitofrontal cortex (OFC) and anterior cingulate cortex volumes at age 12 years mediated a putative association between 5-HTTLPR genotype and first onset of major depressive disorder (MDD) between age 13-19 years, in a longitudinal study of 174 adolescents (48% males). | 25226554 | 2014 | ||||
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0.600 | Biomarker | disease | PSYGENET | This review highlights some research studying changes in the epigenetic patterns intrinsic to genes of 5-HTT and BDNF, which are related to lifelong environmental adversities, which in turn increases the risks of developing MDD. | 24972302 | 2014 | ||||
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0.600 | Biomarker | disease | PSYGENET | This analysis suggests that DNA hypomethylation of the 5-HTT transcriptional control region - possibly via increased serotonin transporter expression and consecutively decreased serotonin availability - might impair antidepressant treatment response in Caucasian patients with MDD. | 24679990 | 2014 | ||||
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0.600 | Biomarker | disease | CTD_human | Serotonin transporter (5HTT) is thought to be involved in the pathophysiology of major depression and the target of antidepressants. | 16055263 | 2005 |