| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.330 | GeneticVariation | disease | BEFREE | TPH-2 Gene Polymorphism in Major Depressive Disorder Patients With Early-Wakening Symptom. | 30519155 | 2018 | ||||
|
0.330 | Biomarker | disease | PSYGENET | Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Malaysian population. | 24376086 | 2015 | ||||
|
0.330 | Biomarker | disease | PSYGENET | Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population. | 26057341 | 2015 | ||||
|
0.330 | Biomarker | disease | PSYGENET | Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation. | 24196946 | 2014 | ||||
|
0.330 | Biomarker | disease | PSYGENET | Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. | 23336047 | 2013 | ||||
|
0.330 | Biomarker | disease | PSYGENET | Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. | 23467366 | 2013 | ||||
|
0.330 | GeneticVariation | disease | BEFREE | There was no association between TPH-2 gene variants and MD in the same population that had shown a strong association with TPH-1. | 17692928 | 2008 | ||||
|
0.330 | Biomarker | disease | BEFREE | Compared to the control group, the HPLC, RT-PCR, and immunohistochemistry results show significant elevation of (1) kynurenine in schizophrenia (1.9-fold, P = 0.02), and in bipolar disorder (1.8-fold, P = 0.04), primarily in the bipolar subgroup with psychosis (2.1-fold, P = 0.03); (2) TDO2 mRNA in schizophrenia (1.7-fold; P = 0.049); and (3) the immunohistochemistry values for the density of TDO2-positive white matter glial cells in schizophrenia (P = 0.01) and in major depression (P = 0.03) as well as the density and intensity of glial cells (in both gray and white matter) stained for TDO2 in bipolar disorder (P = 0.02). | 16448631 | 2006 |