| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | disease | BEFREE | The reduced number of astrocytes may lead to compromised integrity of blood brain barrier with increased monocyte recruitment and infiltration, which is partly supported by post-mortem studies and by PET studies showing an increased TSPO expression in MDD. | 31195092 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | Blood serum concentration of several products known to be synthesized by activated microglia (and to some extent astroglia) [prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), prostaglandin F<sub>2</sub> alpha (PGF<sub>2α</sub>), and tumor necrosis factor alpha (TNF<sub>α</sub>)], controlled by an index of peripheral inflammation [C-reactive protein (CRP)] and TSPO V<sub>T</sub> were measured in 3 cohorts: prefrontal cortex TSPO V<sub>T</sub> of 20 subjects with major depressive episodes (MDEs) from major depressive disorder (MDD); and 56 subjects with treatment resistant MDEs from MDD; and dorsal caudate TSPO V<sub>T</sub> of 20 subjects with obsessive-compulsive disorder. | 31683271 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | Before therapy, TSPO V<sub>T</sub> was significantly elevated in neocortical grey matter, frontal cortex, temporal cortex, and hippocampus in MDD relative to the control subjects. | 29269262 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study. | 28939116 | 2018 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Patients with MDD showed elevated TSPO V<sub>T</sub> in all regions of interest (white matter, grey matter, frontal cortex, temporal cortex, and hippocampus) and were impaired on the attention and delayed memory domains of the RBANS. | 30142589 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Genetic variation in IL-1β, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder. | 26556688 | 2015 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | To explore whether separation anxiety might be a factor differentiating TSPO expression in a sample of patients with major depression. | 18054208 | 2008 |