Out of the eight HSV-2 proteins, the envelope glycoprotein D (gD), the tegument protein VP22 (encoded by the <i>UL49</i> gene), and ribonucleotide reductase subunit 2 protein (RR2; encoded by the <i>UL40</i> gene) produced significant protection against recurrent genital herpes.
Taken together, these preclinical results provide new insights into the immune mechanisms of protection against recurrent genital herpes and promote the tegument RR2 protein as a viable candidate Ag to be incorporated in future genital herpes therapeutic mucosal vaccines.<b>IMPORTANCE</b> Recurrent genital herpes is one of the most common sexually transmitted diseases, with a global prevalence of HSV-2 infection predicted to be over 536 million worldwide.
Out of the eight HSV-2 proteins, the envelope glycoprotein D (gD), the tegument protein VP22 (encoded by the <i>UL49</i> gene), and ribonucleotide reductase subunit 2 protein (RR2; encoded by the <i>UL40</i> gene) produced significant protection against recurrent genital herpes.
Out of the eight HSV-2 proteins, the envelope glycoprotein D (gD), the tegument protein VP22 (encoded by the <i>UL49</i> gene), and ribonucleotide reductase subunit 2 protein (RR2; encoded by the <i>UL40</i> gene) produced significant protection against recurrent genital herpes.
Out of the eight HSV-2 proteins, the envelope glycoprotein D (gD), the tegument protein VP22 (encoded by the <i>UL49</i> gene), and ribonucleotide reductase subunit 2 protein (RR2; encoded by the <i>UL40</i> gene) produced significant protection against recurrent genital herpes.
Low levels of antibody-dependent cellular cytotoxicity-mediating IgG1 and IgG3 antibodies, partly dependent of allotype, may predispose to recurrent genital herpes.
We developed a polymerase chain reaction (PCR) method, based on strain-to-strain variation of DNA repeats in the herpes simplex virus type 2 (HSV-2) genes US1 and US12, to genotype HSV-2 strains and determine the incidence and risk factors associated with HSV-2 superinfection in patients with recurrent genital herpes (RGH).