Gene: BRAF ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 Biomarker disease MGD
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 GeneticVariation disease CLINVAR Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. 12692057 2003
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. 15035987 2004
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 Biomarker disease GENOMICS_ENGLAND HRAS mutations in Costello syndrome: detection of constitutional activating mutations in codon 12 and 13 and loss of wild-type allele in malignancy. 16372351 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 Biomarker disease CLINGEN Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. 16439621 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 Biomarker disease CTD_human Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. 16439621 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 GeneticVariation disease CLINVAR Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. 16439621 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 GeneticVariation disease UNIPROT Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. 16439621 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. 16439621 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 GeneticVariation disease UNIPROT Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. 16474404 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. 16474404 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 GeneticVariation disease BEFREE Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. 16474404 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 Biomarker disease CLINGEN Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. 16474404 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 GeneticVariation disease CLINVAR Distinguishing Costello versus cardio-facio-cutaneous syndrome: BRAF mutations in patients with a Costello phenotype. 16804887 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Distinguishing Costello versus cardio-facio-cutaneous syndrome: BRAF mutations in patients with a Costello phenotype. 16804887 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 Biomarker disease GENOMICS_ENGLAND The cardiofaciocutaneous syndrome. 16825433 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 GermlineCausalMutation disease ORPHANET The cardiofaciocutaneous syndrome. 16825433 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression. 16953233 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 GeneticVariation disease CLINVAR Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: overlapping clinical manifestations with Costello syndrome. 17366577 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 GeneticVariation disease BEFREE Recently, we identified mutations in KRAS and BRAF in 19 of 43 individuals with CFC syndrome, suggesting that dysregulation of the RAS/RAF/MEK/ERK pathway is a molecular basis for CFC syndrome. 17366577 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: overlapping clinical manifestations with Costello syndrome. 17366577 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 GeneticVariation disease BEFREE Leukemia in Cardio-facio-cutaneous (CFC) syndrome: a patient with a germline mutation in BRAF proto-oncogene. 17483702 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. 17496923 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Further delineation of the phenotype resulting from BRAF or MEK1 germline mutations helps differentiate cardio-facio-cutaneous syndrome from Costello syndrome. 17551924 2007