| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | We showed that AR, MMP-9 and EGFR are interconnect factors, which may cooperatively promote PCa progression. | 30134822 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | In this explorative study, CTCs were detected in 98% of M1 patients and detection of EGFR in CTCs was strongly associated with poor outcome, which indicated that phenotypical analysis of CTC could be a promising prognostic marker of ADT-response in castration-naïve metastatic PC patients.Prostate 77:849-858, 2017. | 28295408 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6. | 27746161 | 2017 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Activation of EGFR signaling pathway leads to prostate cancer bone metastasis; however, therapies targeting EGFR have demonstrated limited effectiveness and led to drug resistance. miR-203 levels are down-regulated in clinical samples of primary prostate cancer and further reduced in metastatic prostate cancer. | 25004126 | 2014 | ||||
|
0.070 | Biomarker | disease | BEFREE | Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals. | 19377510 | 2009 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Human epidermal growth factor receptor type 2 protein expression in Chinese metastatic prostate cancer patients correlates with cancer specific survival and increases after exposure to hormonal therapy. | 18645672 | 2008 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | These findings indicate that the combined use of inhibitors of EGF-EGFR and E2-ER-beta signaling with etoposide, which act by increasing the cellular ceramide levels and caspase activity, represents a promising strategy for a more effective treatment of metastatic PC forms. | 17013895 | 2007 |