Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 GeneticVariation disease BEFREE In this study, we examined the diagnostic (n = 77) and relapsed (n = 31) pediatric B-cell acute lymphoblastic leukemia (B-ALL) samples for the most common leukemia-associated gene variations CRLF2, JAK2, PAX5 and IL7R using deep sequencing and copy number alterations (CNAs) (CDKN2A/2B, PAX5, RB1, BTG1, ETV6, CSF2RA, IL3RA and CRLF2) by multiplex ligation proximity assay (MLPA), and evaluated for the clonal changes through relapse. 31228652 2019
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE Regulated Pax5-Etv6 target genes identified in these B-ALLs encode proteins implicated in pre-B-cell receptor (BCR) signaling and migration/adhesion, which could contribute to the proliferation, survival, and tissue infiltration of leukemic B cells. 28219927 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 GeneticVariation disease BEFREE The most common rearrangement in childhood precursor B-cell acute lymphoblastic leukemia is the t(12;21)(p13;q22) translocation resulting in the ETV6-AML1 fusion gene. 27540136 2016
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 AlteredExpression disease BEFREE Further investigation into the clinical and biological significance of elevated MN1 expression in TEL-AML1(positive) leukemia might provide insight into additional molecular mechanisms contributing to B-ALL and may lead to improved treatment options for patients. 26111797 2015
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE The role of ETV6 in B-cell acute lymphoblastic leukemia (ALL) has been extensively studied, whereas only rare cases of ETV6 involvement in pediatric T-cell ALL have been described. 24577543 2014
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE The presence of the type A fusion transcript strongly implies ALL manifestation in ETV6/ABL1-positive hematologic malignancies as minor BCR breakpoint in BCR/ABL1-positive ALL. 23171811 2013
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE A diagnosis of BCR-ABL1 (p190)-positive and ETV6-RUNX1-positive B-ALL was made, and treatment was initiated according to the AIEOP-BFM-ALL2000 protocol. 23491079 2013
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 FusionGene disease ORPHANET A diagnosis of BCR-ABL1 (p190)-positive and ETV6-RUNX1-positive B-ALL was made, and treatment was initiated according to the AIEOP-BFM-ALL2000 protocol. 23491079 2013
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE The degree of anemia was significantly different for three distinct groups of patients compared to the remaining patients (mean hemoglobin; T-cell leukemia: 106 g/L versus 76 g/L (precursor B-cell acute lymphoblastic leukemia); within precursor B-cell ALL: TEL-AML1 positive: 68 g/L versus 79 g/L; BCR-ABL positive: 93 g/L versus 76 g/L; each p<0.05). 18815194 2008
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study. 18928518 2008
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE TEL gene status was determined for 926 patients with B-precursor ALL enrolled on the Pediatric Oncology Group ALinC 16 trials and patients were observed for a median time of 8 years. 18445843 2008
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 GeneticVariation disease BEFREE Here we explore the clonal evolution of a form of childhood precursor-B cell acute lymphoblastic leukemia that is characterized by a chromosomal translocation generating a TEL-AML1 fusion gene. 18202291 2008
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE These cells correspond to TEL/AML1(pos) ALL (1/4 pediatric B-precursor ALL). 18005092 2008
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 GeneticVariation disease BEFREE ETV6-RUNX1 fusion transcripts were detected in 21 of 92 patients (22.8%): 16 with common ALL, 4 with precursor B-cell ALL, and 1 with T-ALL. 17889709 2007
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 GeneticVariation disease BEFREE A t(12;17)(p13;q12) identifies a distinct TEL rearrangement-negative subtype of precursor-B acute lymphoblastic leukemia. 16490598 2006
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE A fluorescence in situ hybridization study of TEL-AML1 fusion gene in B-cell acute lymphoblastic leukemia (1984-2001). 12850377 2003
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 GeneticVariation disease BEFREE TEL is frequently disrupted by chromosomal translocations such as the t(12;21), which is associated with nearly one-fourth of pediatric B cell acute lymphoblastic leukemia. 12626745 2003
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE The IgH, TCR and TEL-AML1 markers can be used as targets by real-time PCR under the same cycling profile, allowing quantitation of MRD in more 95% of patients with pre-B ALL. 12571459 2003
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 GeneticVariation disease BEFREE The t(12;21)(p13;q22) with the TEL-AML1 fusion gene is present in approximately 25% of children with B-precursor ALL. 11841400 2002
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 AlteredExpression disease BEFREE The B-precursor ALL was retransplantable and expressed TEL-AML1. 12124316 2002
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 GeneticVariation disease BEFREE The TEL-AML1 fusion which results from the t(12;21) rearrangement in childhood B-precursor acute lymphoblastic leukaemia (B-precursor ALL) is often accompanied by loss of the untranslocated TEL allele. 11426627 2000
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE However, this group was not representative as it included a high number of relapsed patients compared with the normal incidence in B-precursor ALL [54 in continuous complete remission (CCR) and 36 relapsed patients] and only a slightly better prognosis for TEL/AML1-positive patients was found (not significant) (four relapses in 17 TEL/AML1-positive patients vs. 32 relapses in 73 TEL/AML1-negative patients). 11167743 2000
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 GeneticVariation disease BEFREE Of 166 unselected cases of B-precursor ALL studied by Southern hybridization, 45 cases (27%) showed TEL rearrangement. 9823952 1998
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 GeneticVariation disease BEFREE We show here that a t(9;12)(p24;p13) in a case of early pre-B acute lymphoid leukemia and a t(9;15;12)(p24;q15;p13) in atypical chronic myelogenous leukemia in transformation involve the ETV6 gene at 12p13 and the JAK2 gene at 9p24. 9326218 1997
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.400 Biomarker disease BEFREE Three patients were positive for TEL-AML1 transcripts.All three had common-ALL. 8982044 1996