Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.040 GeneticVariation disease LHGDN The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. 16091753 2005
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.040 GeneticVariation disease BEFREE The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. 16091753 2005
Entrez Id: 5108
Gene Symbol: PCM1
PCM1
0.010 GeneticVariation disease BEFREE The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. 16091753 2005
Entrez Id: 5108
Gene Symbol: PCM1
PCM1
0.010 GeneticVariation disease LHGDN The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. 16091753 2005
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.070 Biomarker disease BEFREE To determine if FLT3 might be involved more widely in BCR-ABL-negative aCML, we analyzed 40 cases and found two were internal tandem duplication-positive, but D835 mutations were not observed. 17764812 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.010 Biomarker disease BEFREE To determine if FLT3 might be involved more widely in BCR-ABL-negative aCML, we analyzed 40 cases and found two were internal tandem duplication-positive, but D835 mutations were not observed. 17764812 2007
Entrez Id: 6711
Gene Symbol: SPTBN1
SPTBN1
0.010 Biomarker disease BEFREE A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy. 17764812 2007
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.040 GeneticVariation disease BEFREE None of the nine amplifiable cases of aCML and none of the normal BM controls showed a JAK2 V617F mutation, in contrast to 45/59 (76%) of the Ph chromosome negative CMPN cases. 18555525 2008
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.040 Biomarker disease LHGDN None of the nine amplifiable cases of aCML and none of the normal BM controls showed a JAK2 V617F mutation, in contrast to 45/59 (76%) of the Ph chromosome negative CMPN cases. 18555525 2008
Entrez Id: 6259
Gene Symbol: RYK
RYK
0.010 GeneticVariation disease BEFREE t(3;21)(q22;q22) leading to truncation of the RYK gene in atypical chronic myeloid leukemia. 19168282 2009
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.040 GeneticVariation disease BEFREE To help identify novel mutations in myeloproliferative neoplasms (MPNs), we performed a genome-wide single nucleotide polymorphism (SNP) screen to identify aUPD in 58 patients with atypical chronic myeloid leukemia (aCML; n = 30), JAK2 mutation-negative myelofibrosis (MF; n = 18), or JAK2 mutation-negative polycythemia vera (PV; n = 10). 19387008 2009
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.020 GeneticVariation disease BEFREE No abnormalities involving tyrosine kinases were detected; however, nine cytogenetically cryptic copy number imbalances were detected in seven patients, including hemizygous deletions of RUNX1 or CEBPA in two cases with atypical chronic myeloid leukemia. 20421268 2010
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.010 GeneticVariation disease BEFREE No abnormalities involving tyrosine kinases were detected; however, nine cytogenetically cryptic copy number imbalances were detected in seven patients, including hemizygous deletions of RUNX1 or CEBPA in two cases with atypical chronic myeloid leukemia. 20421268 2010
Entrez Id: 494336
Gene Symbol: MIR424
MIR424
0.010 Biomarker disease BEFREE Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by real-time polymerase chain reaction (PCR) in bone marrow cells of atypical chronic myeloid leukaemia (aCML, n = 7) and chronic myelomonocytic leukaemia (CMML, n = 8) and were compared to BCR-ABL-positive chronic myelogenous leukaemia (CML, n = 10) and non-neoplastic haematopoiesis (n = 10). 20842500 2011
Entrez Id: 26040
Gene Symbol: SETBP1
SETBP1
0.590 Biomarker disease CTD_human In summary, mutated SETBP1 represents a newly discovered oncogene present in aCML and closely related diseases. 23222956 2013
Entrez Id: 26040
Gene Symbol: SETBP1
SETBP1
0.590 Biomarker disease BEFREE In summary, mutated SETBP1 represents a newly discovered oncogene present in aCML and closely related diseases. 23222956 2013
Entrez Id: 613
Gene Symbol: BCR
BCR
0.090 Biomarker disease BEFREE Atypical chronic myeloid leukemia (aCML) shares clinical and laboratory features with CML, but it lacks the BCR-ABL1 fusion. 23222956 2013
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.070 GeneticVariation disease BEFREE Atypical chronic myeloid leukemia (aCML) shares clinical and laboratory features with CML, but it lacks the BCR-ABL1 fusion. 23222956 2013
Entrez Id: 1441
Gene Symbol: CSF3R
CSF3R
0.590 GeneticVariation disease BEFREE In order to clarify mutational frequency, specificity and phenotypic associations, we sequenced CSF3R exons 14-17 in 54 clinically suspected cases of CNL (n=35) or atypical chronic myeloid leukemia (aCML; n=19). 23604229 2013
Entrez Id: 26040
Gene Symbol: SETBP1
SETBP1
0.590 GeneticVariation disease BEFREE In particular, there was a high frequency of SETBP1 mutation in aCML (19/60; 31.7%) and MDS/MPN unclassifiable (MDS/MPN, U; 20/240; 9.3%). 23628959 2013
Entrez Id: 1441
Gene Symbol: CSF3R
CSF3R
0.590 SomaticCausalMutation disease ORPHANET Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. 23656643 2013
Entrez Id: 26040
Gene Symbol: SETBP1
SETBP1
0.590 GeneticVariation disease BEFREE Here we report whole-exome sequencing of individuals with various myeloid malignancies and identify recurrent somatic mutations in SETBP1, consistent with a recent report on atypical chronic myeloid leukemia (aCML). 23832012 2013
Entrez Id: 1441
Gene Symbol: CSF3R
CSF3R
0.590 GeneticVariation disease BEFREE Recently, we identified high-frequency oncogenic mutations in the granulocyte-colony stimulating factor receptor (CSF3R) in CNL and in some patients with atypical chronic myeloid leukemia. 23896413 2013
Entrez Id: 1441
Gene Symbol: CSF3R
CSF3R
0.590 GeneticVariation disease BEFREE We have recently identified targetable mutations in CSF3R (GCSFR) in 60% of chronic neutrophilic leukemia (CNL) and atypical (BCR-ABL-negative) chronic myeloid leukemia (aCML) patients. 24081659 2013
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.070 Biomarker disease BEFREE We have recently identified targetable mutations in CSF3R (GCSFR) in 60% of chronic neutrophilic leukemia (CNL) and atypical (BCR-ABL-negative) chronic myeloid leukemia (aCML) patients. 24081659 2013