Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.080 AlteredExpression disease BEFREE In the present study, using recombinant purified JAK2JH1-JH2 proteins, we demonstrate that, when activated, wild-type and myeloproliferative neoplasm-associated mutants of JAK2 exhibit comparable enzymatic activity and inhibition by SOCS3 in in vitro kinase assays. 24354892 2014
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.080 GeneticVariation disease BEFREE Interestingly, the SOCS3(F136L) mutation was detected in a Japanese myeloproliferative disorder patient cohort at double the frequency of healthy controls. 19735488 2009
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.080 PosttranslationalModification disease BEFREE Hypermethylation of the SOCS3 promoter was identified in 16 of 50 (32%) patients with idiopathic myelofibrosis but not in patients with essential thrombocythemia, polycythemia vera or myelofibrosis preceded by another myeloproliferative disorder. 18815196 2008
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.080 PosttranslationalModification disease BEFREE The frequent inactivation of SOCS3 is a novel finding in CMPD with potential implications for the molecular pathology of these disorders. 18318760 2008
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.080 PosttranslationalModification disease BEFREE SOCS1, SOCS2 and SOCS3 methylation have been studied in MPN with discordant results. 24131863 2013
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.080 AlteredExpression disease BEFREE Furthermore, curcumin increased the transcript levels of SOCS1 and SOCS3 and significantly inhibited the clonogenic activity of hematopoietic progenitors from patients with MPNs. 23430957 2013
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.080 AlteredExpression disease BEFREE Furthermore, SB increased the transcript levels of SOCS1 and SOCS3 and inhibited the clonogenic activity of hematopoietic progenitors from patients with MPNs. 23111066 2013
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.080 GeneticVariation disease BEFREE Tyrosine-phosphorylated SOCS3 negatively regulates cellular transformation mediated by the myeloproliferative neoplasm-associated JAK2 V617F mutant. 31255914 2019