| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | Interestingly, the SOCS3(F136L) mutation was detected in a Japanese myeloproliferative disorder patient cohort at double the frequency of healthy controls. | 19735488 | 2009 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Tyrosine-phosphorylated SOCS3 negatively regulates cellular transformation mediated by the myeloproliferative neoplasm-associated JAK2 V617F mutant. | 31255914 | 2019 | ||||
|
0.080 | PosttranslationalModification | disease | BEFREE | Hypermethylation of the SOCS3 promoter was identified in 16 of 50 (32%) patients with idiopathic myelofibrosis but not in patients with essential thrombocythemia, polycythemia vera or myelofibrosis preceded by another myeloproliferative disorder. | 18815196 | 2008 | ||||
|
0.080 | PosttranslationalModification | disease | BEFREE | The frequent inactivation of SOCS3 is a novel finding in CMPD with potential implications for the molecular pathology of these disorders. | 18318760 | 2008 | ||||
|
0.080 | PosttranslationalModification | disease | BEFREE | SOCS1, SOCS2 and SOCS3 methylation have been studied in MPN with discordant results. | 24131863 | 2013 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | In the present study, using recombinant purified JAK2JH1-JH2 proteins, we demonstrate that, when activated, wild-type and myeloproliferative neoplasm-associated mutants of JAK2 exhibit comparable enzymatic activity and inhibition by SOCS3 in in vitro kinase assays. | 24354892 | 2014 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Furthermore, curcumin increased the transcript levels of SOCS1 and SOCS3 and significantly inhibited the clonogenic activity of hematopoietic progenitors from patients with MPNs. | 23430957 | 2013 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Furthermore, SB increased the transcript levels of SOCS1 and SOCS3 and inhibited the clonogenic activity of hematopoietic progenitors from patients with MPNs. | 23111066 | 2013 |