Lymphomas were of aggressive B-cell type, extranodal, or leukemic with high MYC expression in the absence of <i>JAK2</i> V617F or other MPN-associated mutations.
To report the demonstration of double minutes with MYC amplification in a case of myeloproliferative neoplasm with monocytosis in transformation by a combination of standard karyotyping and interphase and metaphase fluorescence in situ hybridization (FISH).